Pan Jianzhu, Long Jiaxiang, Ma Guangnai, Li Sheng
Pharmaceutical Department, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Clinical Engineering Department, Guizhou Daqin Cancer Hospital, Guiyang, Guizhou, China.
PLoS One. 2025 Sep 8;20(9):e0322683. doi: 10.1371/journal.pone.0322683. eCollection 2025.
With the rapid development of the nuclear medicine business worldwide, the removal of iodine-131 from specific contaminated environments to protect public health has important application prospects. In this study, the surface decontamination mechanism of Ce(IV)/HNO3 as a decontaminant for iodine-131-contaminated nonmetallic materials was investigated by using an orthogonal experimental method and scanning electron microscopy (SEM). During the preparation experiments with the contaminated materials, both quartz glass and ceramics reached peak activity concentration levels at 4 h of adsorption (contamination) by using immersion; the decontamination factor (DF) was selected as the test index for the decontamination experiments. The influence order of temperature, Ce(IV) concentration, HNO3 concentration and decontamination time on the decontamination factor (DF) was investigated with an orthogonal test and extreme difference analysis. The optimal combination of factors under the set experimental conditions was obtained after a comprehensive analysis. The optimal combination for quartz glass was a decontamination time of 2.0 h>temperature of 60°C > Ce(IV) concentration of 0.02 mol/L > HNO3 concentration of 1.5 mol/L; the optimal combination for the ceramic sheet was a Ce (IV) concentration of 0.02 mol/L>temperature of 80°C >decontamination time of 1 h > HNO3 concentration of 2.0 mol/L. Additionally, from the SEM analysis, the material surface decontamination process removed the surface iodine-131 and the highly accumulated organic substances; overall, a better decontamination effect was achieved.
随着全球核医学业务的快速发展，从特定污染环境中去除碘 - 131以保护公众健康具有重要的应用前景。在本研究中，采用正交实验方法和扫描电子显微镜（SEM）研究了Ce(IV)/HNO₃作为碘 - 131污染非金属材料去污剂的表面去污机理。在对污染材料进行制备实验时，石英玻璃和陶瓷通过浸泡在吸附（污染）4小时时均达到峰值活度浓度水平；去污因子（DF）被选作去污实验的测试指标。通过正交试验和极差分析研究了温度、Ce(IV)浓度、HNO₃浓度和去污时间对去污因子（DF）的影响顺序。经过综合分析，得到了设定实验条件下的最佳因素组合。石英玻璃的最佳组合是去污时间2.0小时>温度60°C>Ce(IV)浓度0.02mol/L>HNO₃浓度1.5mol/L；陶瓷片的最佳组合是Ce(IV)浓度0.02mol/L>温度80°C>去污时间1小时>HNO₃浓度2.0mol/L。此外，通过SEM分析可知，材料表面去污过程去除了表面的碘 - 131和高度积累的有机物质；总体而言，实现了较好的去污效果。
