Biddle F G, MacDonald B G, Eales B A
Can J Genet Cytol. 1985 Dec;27(6):741-50. doi: 10.1139/g85-111.
The genetic control of sex-chromosomal univalency was examined in the primary spermatocytes of the mouse. The C57BL/6J strain expresses 3% X-Y univalency and DBA/2J expresses 37% univalency. The reciprocal F1 and the eight types of reciprocal backcross males were examined. In the C57BL/6J--DBA/2J strain pair, X--Y univalency is controlled by three genetic systems. Autosomal factors of unknown number that are dominant in DBA/2J increase the probability of univalency from 3% in C57BL/6J to 12%. The DBA/2J-Y chromosome, in place of the C57BL/6J-Y chromosome, has an additive effect to increase the probability of univalency from 12 to 37% in the DBA/2J strain. Two X-chromosome factors that differ between C57BL/6J and DBA/2J regulate the probability of univalency. The X-chromosome factors appear to be separated by sufficient distance so that, with the DBA/2J-Y chromosome and dominant DBA/2J autosomal factors, there are two recombinant classes of X--Y univalency at 20 and 60%. The genetic factors in the univalency trait may be involved in the regulation or structure of the terminal attachment sites between the X and Y chromosomes.
在小鼠的初级精母细胞中研究了性染色体单价体的遗传控制。C57BL/6J品系表现出3%的X-Y单价体，而DBA/2J品系表现出37%的单价体。对正反交F1代以及八种类型的正反交回交雄性小鼠进行了研究。在C57BL/6J-DBA/2J品系对中，X-Y单价体由三个遗传系统控制。数量未知的常染色体因子在DBA/2J中占主导地位，可将单价体出现的概率从C57BL/6J中的3%提高到12%。用DBA/2J-Y染色体取代C57BL/6J-Y染色体，具有累加效应，可使DBA/2J品系中单价体出现的概率从12%提高到37%。C57BL/6J和DBA/2J之间存在差异的两个X染色体因子调节单价体出现的概率。X染色体因子似乎相隔足够远的距离，因此，在DBA/2J-Y染色体和占主导地位的DBA/2J常染色体因子存在的情况下，有两种重组类型的X-Y单价体，出现概率分别为20%和60%。单价体性状中的遗传因子可能参与X和Y染色体之间末端附着位点的调控或结构形成。
