C57BL/6J与（C57BL/6J×DBA/2J）F1小鼠杂交后代中，小鼠11号染色体的性别限制非孟德尔遗传。

Sex-restricted non-Mendelian inheritance of mouse chromosome 11 in the offspring of crosses between C57BL/6J and (C57BL/6J x DBA/2J)F1 mice.

作者信息

Shendure J, Melo J A, Pociask K, Derr R, Silver L M

机构信息

Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014, USA.

出版信息

Mamm Genome. 1998 Oct;9(10):812-5. doi: 10.1007/s003359900872.

DOI:10.1007/s003359900872

PMID:9745035

Abstract

We report on the observation of sex-restricted, non-Mendelian inheritance over a region of mouse Chromosome (Chr) 11, occurring in the offspring of crosses between two commonly used Mus musculus-derived inbred strains, C57BL/6J and DBA/2J. In the surviving backcross progeny of reciprocal matings between (C57BL/6J x DBA/2J)F1 hybrids and the C57BL/6J parental strain, we observed the preferential appearance of C57BL/6J alleles along a region of Chr 11. The deviation from Mendelian predictions was observed only in female offspring from both reciprocal backcrosses, and not in males from either cross. The sex-specificity of the observed non-Mendelian inheritance points to an explanation based on embryonic or neonatal lethality. Our data add to previously obtained evidence for a Chr 11 locus or loci with sex-specific and allele-specific effects on viability.

摘要

我们报告了在小鼠11号染色体（Chr）一个区域观察到的性别受限、非孟德尔遗传现象，该现象出现在两个常用的小家鼠衍生近交系C57BL/6J和DBA/2J杂交后代中。在（C57BL/6J×DBA/2J）F1杂种与C57BL/6J亲本品系的正反交回交后代中，我们观察到C57BL/6J等位基因在11号染色体的一个区域优先出现。这种偏离孟德尔预测的现象仅在两个正反交回交的雌性后代中观察到，而在任何一个杂交组合的雄性后代中均未观察到。观察到的非孟德尔遗传的性别特异性指向基于胚胎或新生儿致死性的解释。我们的数据补充了先前获得的证据，表明11号染色体上存在一个或多个对生存能力有性别特异性和等位基因特异性影响的基因座。