美国老年人群维生素K摄入量与牙周炎之间的关联：对美国国家健康与营养检查调查（NHANES）数据的横断面分析

Association between vitamin K intake and periodontitis in American elderly population: a cross-sectional analysis of NHANES data.

作者信息

Zhu Long, Liang Si, Yang Yang, Su Ziqi, Ou Lijia, Zhang Weimeng, Liu Binjie, Liu Ousheng, Feng Hui

机构信息

Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxillofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, 410008, Hunan, PR China.

State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Chinese Academy of Medical Sciences, Sichuan University, Chengdu, 610041, Sichuan, China.

出版信息

Clin Oral Investig. 2025 Sep 9;29(10):442. doi: 10.1007/s00784-025-06527-7.

DOI:10.1007/s00784-025-06527-7

PMID:40921882

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12417290/

Abstract

BACKGROUND

An increasing amount of data has been acquired on the close relationship between Vitamin K intake and the progression of periodontitis. The purpose of this study was to estimate whether Vitamin K intake is associated with periodontitis among older adults in America using information from the National Health and Nutrition Examination Survey (NHANES) database.

METHODS

A cross-sectional analysis of data on periodontal indices and vitamin K intake among American adults aged 60 years and older in the 2009-2014 NHANES database was extracted. Periodontitis was defined according to CDC/AAP criteria, classification of periodontitis and severity of periodontitis according to the degree and amount of attachment loss in the interproximal site, and vitamin K intake was categorized using optimal cutoff value. Univariate and multivariate logistic regression analyses were used to investigate the association between vitamin K intake and the risk of periodontitis.

RESULTS

Based on the information analysis of 2303 participants who met the inclusion criteria, the risk of periodontitis was lower in the elderly population with higher vitamin K intake. Especially, a statistically significant reduction in the prevalence of periodontitis was observed in elderly populations with vitamin K intake greater than 89.51 mg/d (OR = 0.648,95%Cl = 0.502-0.837, P value = 0.001) compared to those with vitamin K intake less than 89.51 mg/d. Subgroup analyses revealed that this association was more prominent in elderly people aged 60-69 years and 70-79 years, the female/male population, the Non-Hispanic White population, those with a poverty index of 1.3-3.5, education level over high school grad/GED, non-smokers, 1-5 drinks/month, non-alcohol drinkers, overweight, normal blood pressure and without diabetes.

CONCLUSION

Our research found a strong relationship between vitamin K intake and periodontitis among elderly people in the United States, suggesting vitamin K intake is a possible risk factor and may be a novel idea for the diagnosis and treatment of periodontitis.

摘要

背景

关于维生素K摄入量与牙周炎进展之间的密切关系，已获取越来越多的数据。本研究的目的是利用美国国家健康与营养检查调查（NHANES）数据库中的信息，评估美国老年人中维生素K摄入量是否与牙周炎有关。

方法

从2009 - 2014年NHANES数据库中提取美国60岁及以上成年人牙周指数和维生素K摄入量的数据进行横断面分析。根据美国疾病控制与预防中心（CDC）/美国牙周病学会（AAP）标准定义牙周炎，根据邻面附着丧失的程度和量对牙周炎进行分类和严重程度评估，并使用最佳临界值对维生素K摄入量进行分类。采用单因素和多因素逻辑回归分析来研究维生素K摄入量与牙周炎风险之间的关联。

结果

基于对2303名符合纳入标准参与者的信息分析，维生素K摄入量较高的老年人群患牙周炎的风险较低。特别是，与维生素K摄入量低于89.51mg/d的老年人群相比，维生素K摄入量大于89.51mg/d的老年人群中牙周炎患病率有统计学意义的降低（OR = 0.648，95%CI = 0.502 - 0.837，P值 = 0.001）。亚组分析显示，这种关联在60 - 69岁和70 - 79岁的老年人、女性/男性人群、非西班牙裔白人人群、贫困指数为1.3 - 3.5的人群、高中以上学历/同等学历人群、非吸烟者、每月饮酒1 - 5次者、不饮酒者、超重者、血压正常且无糖尿病者中更为显著。