Su Qimeng, Sun Shan, Xing Shanghua, Tan Mingqian
State Key Laboratory of Marine Food Processing and Safety Control, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, Liaoning, China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China.; Dalian Key Laboratory for Precision Nutrition, Dalian Polytechnic University, Dalian 116034, Liaoning, China.
State Key Laboratory of Marine Food Processing and Safety Control, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, Liaoning, China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China.; Dalian Key Laboratory for Precision Nutrition, Dalian Polytechnic University, Dalian 116034, Liaoning, China.
Food Res Int. 2025 Nov;219:117020. doi: 10.1016/j.foodres.2025.117020. Epub 2025 Jul 24.
Anthocyanins (AC) are natural bioactive substances with the excellent antioxidant properties, but its structure is susceptible to the external environmental factors with inevitably decreased bioavailability. In this work, γ-cyclodextrin based metal-organic framework (CD-MOF) shows high encapsulation efficiency (96.09 %) and satisfiable loading amount (24.98 mg/g). Attributed to multiple hydrogen bonding and dispersion interactions between encapsulated AC and CD-MOF, CD-MOF could improve the AC stability against heating, irradiation and gastrointestinal digestion. Furthermore, the anti-oxidative stress effect of AC@CD-MOF was evaluated by using the model organism of Caenorhabditis elegans. AC@CD-MOF could prolong the lifespan, increase reproductive ability and improve the body length, by improving antioxidant enzyme activity and decreasing malondialdehyde content, ROS levels and lipofuscin accumulation. Compared to free AC, AC@CD-MOF showed the lower aging-induced oxidative stress. This work demonstrates the effective protection of AC by CD-MOF with improved antioxidative effect and provide a guidance for developing as anti-aging supplement.
花青素（AC）是具有优异抗氧化性能的天然生物活性物质，但其结构易受外部环境因素影响，生物利用度不可避免地降低。在本研究中，基于γ-环糊精的金属有机框架（CD-MOF）表现出高包封率（96.09%）和令人满意的负载量（24.98 mg/g）。由于被包封的AC与CD-MOF之间存在多重氢键和分散相互作用，CD-MOF可以提高AC对加热、辐照和胃肠道消化的稳定性。此外，通过使用秀丽隐杆线虫作为模式生物评估了AC@CD-MOF的抗氧化应激作用。AC@CD-MOF可以通过提高抗氧化酶活性、降低丙二醛含量、ROS水平和脂褐素积累来延长寿命、提高繁殖能力并增加体长。与游离AC相比，AC@CD-MOF表现出较低的衰老诱导氧化应激。这项工作证明了CD-MOF对AC的有效保护，具有改善的抗氧化作用，并为开发抗衰老补充剂提供了指导。
