Xu Yuncong, Yang Yuhui, Jiang Yuge, Li Bowen, Xie Yanli, Shi Yonghui, Le Guowei
Henan Key Laboratory of Cereal and Oil Food Safety and Nutrition, College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001, Henan, China; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, Jiangsu, China.
Henan Key Laboratory of Cereal and Oil Food Safety and Nutrition, College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001, Henan, China.
Food Res Int. 2025 Nov;219:116858. doi: 10.1016/j.foodres.2025.116858. Epub 2025 Jun 11.
Cognitive disorders, a rapidly growing public health concern, can be prevented by a healthy diet. Several studies have shown that protein intake is a key modulator of cognitive function. The development of precision nutrition has allowed the study of specific amino acids within proteins, with many studies reporting that the level of methionine (Met) intake plays a central role in modulating cognitive function. Methionine has both beneficial and detrimental effects on cognitive function, depending on various factors, and a comprehensive summary of its effects on brain health is urgently required. Here, the effects of different Met intakes on cognitive function were systematically reviewed. The effects of Met on learning and memory are strongly correlated with different intervention doses and periods, and the sex, age, and physiological status of the recipients. Furthermore, the mechanisms underlying the effects of Met were discussed, which acts through reduction-oxidation homeostasis, gut microbiota alterations, and epigenetic modifications. Moreover, methods of altering Met levels in the body are comprehensively summarized, and strategy for achieving precise Met nutrition was summarized and proposed. In summary, precise Met nutrition for cognitive function is important. Improvements in brain function may be achieved by adjusting dietary Met levels, which is convenient, efficient, and worthy of further investigation.
认知障碍是一个迅速增长的公共卫生问题，健康饮食可以预防。多项研究表明，蛋白质摄入是认知功能的关键调节因素。精准营养的发展使得对蛋白质中特定氨基酸的研究成为可能，许多研究报告称，蛋氨酸（Met）的摄入量在调节认知功能方面起着核心作用。蛋氨酸对认知功能既有有益影响，也有有害影响，这取决于各种因素，因此迫切需要对其对大脑健康的影响进行全面总结。在此，系统综述了不同蛋氨酸摄入量对认知功能的影响。蛋氨酸对学习和记忆的影响与不同的干预剂量、周期以及接受者的性别、年龄和生理状态密切相关。此外，还讨论了蛋氨酸作用的潜在机制，其通过氧化还原稳态、肠道微生物群改变和表观遗传修饰发挥作用。此外，还全面介绍了改变体内蛋氨酸水平的方法，并总结并提出了实现精准蛋氨酸营养的策略。总之，精准的蛋氨酸营养对认知功能很重要。通过调整饮食中的蛋氨酸水平可能实现脑功能的改善，这既方便又有效，值得进一步研究。
