Shi Xiaoyu, Shi Lingyun, Tian Yukui, Li Ning
Department of Spinal Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Department of Tuina, Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Academy of Traditional Chinese Medicine, Urumqi, China.
Medicine (Baltimore). 2025 Sep 5;104(36):e43835. doi: 10.1097/MD.0000000000043835.
Functional constipation (FC) is a prevalent gastrointestinal disorder that can significantly impact patients' quality of life. In this study, we aimed to evaluate the effectiveness and safety of "abdominal tuina" and oral mosapride citrate tablets in the treatment of FC. Ninety patients with FC were randomly assigned to receive either "abdominal tuina" treatment or oral mosapride citrate tablets. Symptom scores, quality of life assessments, physiological and biochemical indicators, and mental health parameters were monitored at various time points during the 90-day treatment period. Significant improvement in clinical symptom scores was observed in the experimental group by day 10, with sustained efficacy throughout the study. The experimental group demonstrated superior effectiveness and improvements in biochemical markers and mental health scores compared to the control group. No significant adverse reactions were reported in either group. The study findings suggest that "abdominal tuina" treatment and oral mosapride citrate tablets are equally effective in managing FC, with both interventions effectively reducing symptoms and enhancing quality of life without significant adverse effects. The maintenance of treatment effects at day 10 highlights the potential benefits of these therapies for FC patients.
功能性便秘（FC）是一种常见的胃肠道疾病，会对患者的生活质量产生重大影响。在本研究中，我们旨在评估“腹部推拿”和口服枸橼酸莫沙必利片治疗FC的有效性和安全性。90例FC患者被随机分配接受“腹部推拿”治疗或口服枸橼酸莫沙必利片。在90天的治疗期内，在不同时间点监测症状评分、生活质量评估、生理和生化指标以及心理健康参数。实验组在第10天时临床症状评分有显著改善，且在整个研究过程中疗效持续。与对照组相比，实验组在生化指标和心理健康评分方面表现出更优的有效性和改善。两组均未报告明显不良反应。研究结果表明，“腹部推拿”治疗和口服枸橼酸莫沙必利片在管理FC方面同样有效，两种干预措施均能有效减轻症状并提高生活质量，且无明显不良反应。第10天时治疗效果的维持突出了这些疗法对FC患者的潜在益处。
