Novin Kambiz, Shahrokh Soroush, Shahin Mohadese, Taghizadeh-Hesary Farzad
Radiation Oncology Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Cancer Rep (Hoboken). 2025 Sep;8(9):e70346. doi: 10.1002/cnr2.70346.
To present a case of metastatic endometrial carcinosarcoma (ECS) with a long-term complete response to chemotherapy using a paclitaxel and carboplatin regimen.
A 47-year-old premenopausal woman was diagnosed with a large, advanced intrauterine tumor. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Pathological assessment revealed a uterine mass with mesenchymal and epithelial components consistent with ECS, while the right ovarian tumor was identified as serous papillary carcinoma. The patient experienced a prolonged postoperative recovery period lasting 3 months. Staging workup later revealed recurrence of adnexal and pulmonary lesions, indicating metastasis. The patient received 6 cycles of postoperative chemotherapy consisting of paclitaxel and carboplatin, achieving complete remission that has persisted for 3 years since the initial diagnosis.
This case highlights the efficacy of postoperative chemotherapy using paclitaxel and carboplatin in the successful treatment of metastatic ECS.
报告一例转移性子宫内膜癌肉瘤（ECS）患者，其采用紫杉醇和卡铂方案化疗后获得长期完全缓解。
一名47岁绝经前女性被诊断为患有巨大的晚期子宫内肿瘤。她接受了全腹子宫切除术及双侧输卵管卵巢切除术。病理评估显示子宫肿物具有与ECS一致的间叶和上皮成分，而右侧卵巢肿瘤被确定为浆液性乳头状癌。患者术后恢复期延长，持续了3个月。后期分期检查显示附件和肺部病变复发，提示转移。患者接受了6个周期的术后化疗，化疗方案为紫杉醇和卡铂，自初次诊断以来已实现完全缓解并持续了3年。
本病例突出了紫杉醇和卡铂术后化疗在成功治疗转移性ECS中的疗效。
