Narimani Samaneh, Rahbarghazi Reza, Salehipourmehr Hanieh, Taghavi Narmi Maryam, Lotfimehr Hamid, Mehdipour Robab
Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Adv Pharm Bull. 2025 Jun 16;15(2):268-283. doi: 10.34172/apb.025.45122. eCollection 2025 Jul.
Myocardial infarction (MI), the leading cause of human mortality, is induced by a sudden interruption of blood supply. Among various stem cell types, endothelial progenitor cells (EPCs) are novel and valid cell sources for the restoration of vascularization in the ischemic tissue. The present study aimed to evaluate the regenerative properties of EPCs in rodent models of MI.
A comprehensive systematic search was implemented in Cochrane Library, Embase, PubMed, Scopus, and Web of Science databases without language limitation in Sep 2024. Of the 67 papers pooled, 42 met the inclusion criteria and were subjected to multiple analyses.
Compared to the MI group, the overall effect size was confirmed in the groups receiving EPC with enhanced angiogenesis (SMD: 2.02, CI 95%: 1.51-2.54, <0.00001; I: 82%), reduced fibrosis (SMD: -1.48; 95% CI-2.15, -0.81; <0.0001; I: 88%), improved ejection fraction (EF; SMD: 1.72; 95% CI-1.21, 2.23; <0.00001; I: 87%), and fractional shortening (FS; SMD: 1.58; 95% CI-1.13, 2.03; <0.00001; I: 82%). Data confirmed significant improvements in the cardiac tissue parameters after intramyocardial injection of EPCs.
These data showed that EPC transplantation is an alternative therapy to ameliorate ischemic myocardium in rodents via the stimulation of angiogenesis, reduction of fibrosis, and improvement of fractional shortening and ejection fraction.
心肌梗死（MI）是人类死亡的主要原因，由血液供应突然中断引起。在各种干细胞类型中，内皮祖细胞（EPCs）是用于恢复缺血组织血管化的新型有效细胞来源。本研究旨在评估EPCs在MI啮齿动物模型中的再生特性。
2024年9月，在Cochrane图书馆、Embase、PubMed、Scopus和Web of Science数据库中进行了全面的系统检索，无语言限制。在汇总的67篇论文中，42篇符合纳入标准并进行了多项分析。
与MI组相比，接受EPCs的组在增强血管生成（标准化均数差：2.02，95%置信区间：1.51 - 2.54，<0.00001；I²：82%）、减少纤维化（标准化均数差：-1.48；95%置信区间-2.15，-0.81；<0.0001；I²：88%）、改善射血分数（EF；标准化均数差：1.72；95%置信区间-1.21，2.23；<0.00001；I²：87%）和缩短分数（FS；标准化均数差：1.58；95%置信区间-1.13，2.03；<0.00001；I²：82%）方面证实了总体效应大小。数据证实心肌内注射EPCs后心脏组织参数有显著改善。
这些数据表明，EPC移植是一种替代疗法，可通过刺激血管生成、减少纤维化以及改善缩短分数和射血分数来改善啮齿动物的缺血心肌。
