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内皮祖细胞用于构建工程化血管单位和血管生成诱导。

Endothelial progenitor cells for fabrication of engineered vascular units and angiogenesis induction.

机构信息

Department of Medical Biotechnology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.

出版信息

Cell Prolif. 2024 Sep;57(9):e13716. doi: 10.1111/cpr.13716. Epub 2024 Jul 25.

DOI:10.1111/cpr.13716
PMID:39051852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11503262/
Abstract

The promotion of vascularization and angiogenesis in the grafts is a crucial phenomenon in the healing process and tissue engineering. It has been shown that stem cells, especially endothelial progenitor cells (EPCs), can stimulate blood vessel formation inside the engineered hydrogels after being transplanted into the target sites. The incorporation of EPCs into the hydrogel can last the retention time, long-term survival, on-target delivery effects, migration and differentiation into mature endothelial cells. Despite these advantages, further modifications are mandatory to increase the dynamic growth and angiogenesis potential of EPCs in in vitro and in vivo conditions. Chemical modifications of distinct composites with distinct physical properties can yield better regenerative potential and angiogenesis during several pathologies. Here, we aimed to collect recent findings related to the application of EPCs in engineered vascular grafts and/or hydrogels for improving vascularization in the grafts. Data from the present article can help us in the application of EPCs as valid cell sources in the tissue engineering of several ischemic tissues.

摘要

促进移植物中的血管生成和血管生成是愈合过程和组织工程中的一个关键现象。已经表明，干细胞，特别是内皮祖细胞（EPC），可以在移植到靶位后刺激工程化水凝胶内的血管形成。EPC 被掺入水凝胶中可以保持保留时间、长期存活、靶向递送效果、迁移和分化为成熟的内皮细胞。尽管有这些优点，但仍需要进一步的修饰来增加 EPC 在体外和体内条件下的动态生长和血管生成潜力。不同物理性质的不同复合材料的化学修饰可以在多种病理条件下产生更好的再生潜力和血管生成。在这里，我们旨在收集与 EPC 在用于改善移植物中血管化的工程血管移植物和/或水凝胶中的应用相关的最新发现。本文的数据可以帮助我们将 EPC 作为几种缺血组织的组织工程中有效的细胞来源进行应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10de/11503262/278e2e58394f/CPR-57-e13716-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10de/11503262/351e72c24411/CPR-57-e13716-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10de/11503262/278e2e58394f/CPR-57-e13716-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10de/11503262/e332f077cebd/CPR-57-e13716-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10de/11503262/2a10f81fbb08/CPR-57-e13716-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10de/11503262/f056e9486b9c/CPR-57-e13716-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10de/11503262/bec61b785128/CPR-57-e13716-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10de/11503262/aa93d3b3523e/CPR-57-e13716-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10de/11503262/351e72c24411/CPR-57-e13716-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10de/11503262/278e2e58394f/CPR-57-e13716-g005.jpg

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