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Inhibition of COX-2 and PI3K/AKT Pathways to Prevent Cancer Metastasis.

作者信息

Kumar Punet, Singh Sangam

机构信息

Department of Pharmaceutical Chemistry, Shri Gopichand College of Pharmacy, Dr. A.P.J. Abdul Kalam Technical University, Baghpat, India.

Department of Pharmaceutical Chemistry, Oxford College of Pharmacy, Dr. A.P.J. Abdul Kalam Technical University, Hapur, India.

出版信息

Adv Pharm Bull. 2025 Mar 23;15(2):230-231. doi: 10.34172/apb.44038. eCollection 2025 Jul.

DOI:10.34172/apb.44038
PMID:40922756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12413970/
Abstract
摘要

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本文引用的文献

1
Cancer stem cells: advances in knowledge and implications for cancer therapy.癌症干细胞：知识进展及其对癌症治疗的影响。
Signal Transduct Target Ther. 2024 Jul 5;9(1):170. doi: 10.1038/s41392-024-01851-y.
2
Targeting inflammation as cancer therapy.靶向炎症作为癌症治疗方法。
J Hematol Oncol. 2024 Mar 22;17(1):13. doi: 10.1186/s13045-024-01528-7.
3
Advancements in dual-target inhibitors of PI3K for tumor therapy: Clinical progress, development strategies, prospects.PI3K 双重抑制剂在肿瘤治疗中的研究进展：临床进展、研发策略、前景展望。
Eur J Med Chem. 2024 Feb 5;265:116109. doi: 10.1016/j.ejmech.2023.116109. Epub 2023 Dec 31.
4
Recent advances in targeting the "undruggable" proteins: from drug discovery to clinical trials.靶向“不可成药”蛋白的最新进展：从药物发现到临床试验。
Signal Transduct Target Ther. 2023 Sep 6;8(1):335. doi: 10.1038/s41392-023-01589-z.
5
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer.PI3K/AKT/mTOR 信号转导通路与癌症的靶向治疗。
Mol Cancer. 2023 Aug 18;22(1):138. doi: 10.1186/s12943-023-01827-6.
6
Protective Effects of Long-Term Usage of Cyclo-Oxygenase-2 Inhibitors on Colorectal Cancer in Genetically Predisposed Individuals and Their Overall Effect on Prognosis: A Systematic Review.长期使用环氧化酶-2抑制剂对遗传易感性个体结直肠癌的保护作用及其对预后的总体影响：一项系统评价
Cureus. 2023 Jul 15;15(7):e41939. doi: 10.7759/cureus.41939. eCollection 2023 Jul.
7
The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds.PI3K-Akt-mTOR 及相关信号通路作为免疫介导性炎症性皮肤病的分子驱动因素：天然和合成化合物治疗策略的最新进展。
Cells. 2023 Jun 20;12(12):1671. doi: 10.3390/cells12121671.
8
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth.不断演变的肿瘤微环境：从癌症起始到转移灶生长
Cancer Cell. 2023 Mar 13;41(3):374-403. doi: 10.1016/j.ccell.2023.02.016.
9
Recent progress on FAK inhibitors with dual targeting capabilities for cancer treatment.FAK 抑制剂在癌症治疗中双重靶向能力的最新进展。
Biomed Pharmacother. 2022 Jul;151:113116. doi: 10.1016/j.biopha.2022.113116. Epub 2022 May 19.
10
Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations.癌细胞诱导的 COX-2 上调定义了它们的炎症特性，并限制了化疗免疫治疗联合的疗效。
Nat Commun. 2022 Apr 19;13(1):2063. doi: 10.1038/s41467-022-29606-9.