Kalra Saurabh, Kleiman Evan M, Rizvi Shireen L, Grafova Irina B, Duberstein Paul R, Kalra Deepak
Miller School of Medicine, University of Miami, Miami, Florida.
Rutgers University, New Brunswick, New Jersey.
JAACAP Open. 2024 Nov 29;3(3):548-556. doi: 10.1016/j.jaacop.2024.11.005. eCollection 2025 Sep.
Food allergy (FA) is a growing public health concern that has been associated with feelings of sadness, hopelessness, shorter sleep duration, and being bullied-all linked to suicide risk. Given the limited prior research, this study aimed to examine the association between FA and suicidal behavior.
Data from the Centers for Disease Control and Prevention Youth Risk Behavior Survey (2015-2019) were analyzed. This nationally representative sample included 22,017 adolescents 14 to 18 years old. To assess the association between FA and medically serious suicide attempts, several multivariate logistic regressions were conducted adjusting for effects of sadness/hopelessness, suicidal ideation, shorter sleep duration, being bullied, physical activity, and other covariates. Additionally, a sensitivity analysis was conducted to explore the association between FA and all suicide attempts, including attempts not requiring medical attention.
Among the participants, 15.6% (n = 3,435) reported FA, and 2.3% (n = 501) reported serious suicide attempts. Within the serious suicide attempt group, 31.9% (n = 160) reported FA compared with 15.2% (n = 3,275) among participants who did not report serious suicide attempts. Multivariate analyses revealed that adolescents with FA had higher odds of reporting suicide attempts requiring medical intervention (adjusted odds ratio 1.63, 95% CI 1.23-2.16). In the sensitivity analysis, FA continued to show significance when broadening the outcome to include all suicide attempts, regardless of whether medical attention was required (adjusted odds ratio 1.35, 95% CI 1.09-1.68).
Health care practitioners caring for adolescents with FA should be cognizant of their increased susceptibility for suicidal behavior.
食物过敏（FA）是一个日益引起公众健康关注的问题，它与悲伤、绝望、睡眠时间缩短以及被欺负等情绪有关，而这些都与自杀风险相关。鉴于先前的研究有限，本研究旨在探讨食物过敏与自杀行为之间的关联。
对疾病控制与预防中心青少年风险行为调查（2015 - 2019年）的数据进行分析。这个具有全国代表性的样本包括22017名14至18岁的青少年。为了评估食物过敏与需要医疗救治的严重自杀未遂之间的关联，进行了多项多因素逻辑回归分析，对悲伤/绝望、自杀意念、睡眠时间缩短、被欺负、体育活动及其他协变量的影响进行了校正。此外，还进行了敏感性分析，以探讨食物过敏与所有自杀未遂之间的关联，包括那些不需要医疗救治的自杀未遂。
在参与者中，15.6%（n = 3435）报告有食物过敏，2.3%（n = 501）报告有严重自杀未遂。在严重自杀未遂组中，31.9%（n = 160）报告有食物过敏，而在未报告严重自杀未遂的参与者中这一比例为15.2%（n = 3275）。多因素分析显示，患有食物过敏的青少年报告需要医疗干预的自杀未遂的几率更高（校正比值比1.63，95%置信区间1.23 - 2.16）。在敏感性分析中，当将结果扩大到包括所有自杀未遂（无论是否需要医疗救治）时，食物过敏仍然显示出显著性（校正比值比1.35，95%置信区间1.09 - 1.68）。
照顾患有食物过敏青少年的医护人员应意识到他们自杀行为的易感性增加。
