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脑静脉血栓形成:现状与挑战

Cerebral Venous Thrombosis:Current Status and Challenges.

作者信息

Zuo Wenbo, Chen Shengcai, Lin Jiashuo, Wan Yan, Cao Fei, Hu Bo

机构信息

Department of neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

Brain Behav. 2025 Sep;15(9):e70844. doi: 10.1002/brb3.70844.

Abstract

BACKGROUND

Cerebral venous thrombosis (CVT) is a stroke type that primarily affects young individuals, with various risk factors and complex mechanisms. It accounts for 0.5% to 3% of all stroke cases and can significantly impact daily activities and quality of life.

OBJECTIVE

This review aims to classify the etiology of CVT, assess its impact on prognosis, and evaluate the best treatment approaches. It also analyzes current issues in CVT management and proposes future directions for treatment.

METHODS

A comprehensive review of the literature on CVT, focusing on risk factors, treatment strategies, and outcomes. The impact of anticoagulation therapy and endovascular interventions is examined.

RESULTS

This review examines the various risk factors associated with CVT, including female-specific conditions, infections, autoimmune diseases, cancer, and mechanical triggers. It highlights the impact of these factors on the prognosis and outcomes of CVT. The effectiveness of anticoagulation therapy, both traditional and with direct oral anticoagulants, is discussed, along with the role of endovascular therapy in severe cases. The review also identifies current challenges in CVT management, such as incomplete thrombus clearance and the lack of standardized evaluation criteria for recanalization.

CONCLUSION

Further research is needed to optimize CVT management, improve patient outcomes, and enhance the quality of life for affected individuals.

摘要

背景

脑静脉血栓形成(CVT)是一种主要影响年轻人的卒中类型,具有多种危险因素和复杂机制。它占所有卒中病例的0.5%至3%,可显著影响日常活动和生活质量。

目的

本综述旨在对CVT的病因进行分类,评估其对预后的影响,并评价最佳治疗方法。它还分析了CVT管理中的当前问题,并提出了未来的治疗方向。

方法

对关于CVT的文献进行全面综述,重点关注危险因素、治疗策略和结果。研究抗凝治疗和血管内介入的影响。

结果

本综述研究了与CVT相关的各种危险因素,包括女性特有的情况、感染、自身免疫性疾病、癌症和机械触发因素。它强调了这些因素对CVT预后和结果的影响。讨论了传统抗凝治疗和直接口服抗凝剂的有效性,以及血管内治疗在严重病例中的作用。该综述还确定了CVT管理中的当前挑战,如血栓清除不完全和再通缺乏标准化评估标准。

结论

需要进一步研究以优化CVT管理,改善患者预后,并提高受影响个体的生活质量。

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