癌症干细胞中转录因子Etv1的类泛素化修饰诱导非干细胞性癌细胞发生肿瘤形成。
SUMOylation of the transcription factor Etv1 in cancer stem cells induces tumorigenesis of non-stem cancer cells.
作者信息
Chen Yuan
机构信息
Division of Surgical Sciences, Department of Surgery, UC San Diego Health, 3855 Health Sciences Drive, La Jolla, CA 92037, USA.
出版信息
Dev Cell. 2025 Sep 8;60(17):2213-2214. doi: 10.1016/j.devcel.2025.06.023.
PMID:40925324
Abstract
In this issue of Developmental Cell, Li et al. show that ETS variant transcription factor 1 (Etv1) SUMOylation not only maintains cancer stem cells (CSCs) but also enables their communications with non-CSC cancer cells to induce tumorigenesis of non-CSCs. The finding reveals a new function of CSCs in driving aggressive tumorigenesis that is SUMOylation dependent.
摘要
在本期《发育细胞》杂志中，李等人表明，ETS变异转录因子1（Etv1）的SUMO化不仅维持癌症干细胞（CSCs），还使其能够与非CSC癌细胞进行通讯，从而诱导非CSC的肿瘤发生。这一发现揭示了CSCs在驱动依赖SUMO化的侵袭性肿瘤发生中的新功能。
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