Chen Yuan
Division of Surgical Sciences, Department of Surgery, UC San Diego Health, 3855 Health Sciences Drive, La Jolla, CA 92037, USA.
Dev Cell. 2025 Sep 8;60(17):2213-2214. doi: 10.1016/j.devcel.2025.06.023.
In this issue of Developmental Cell, Li et al. show that ETS variant transcription factor 1 (Etv1) SUMOylation not only maintains cancer stem cells (CSCs) but also enables their communications with non-CSC cancer cells to induce tumorigenesis of non-CSCs. The finding reveals a new function of CSCs in driving aggressive tumorigenesis that is SUMOylation dependent.
在本期《发育细胞》杂志中，李等人表明，ETS变异转录因子1（Etv1）的SUMO化不仅维持癌症干细胞（CSCs），还使其能够与非CSC癌细胞进行通讯，从而诱导非CSC的肿瘤发生。这一发现揭示了CSCs在驱动依赖SUMO化的侵袭性肿瘤发生中的新功能。
