Panlilio Mia, Tchernogorova Elizabeth, Nguyen Binh Minh, Khan Sana, Torgerson Leslie
College of Osteopathic Medicine, Rocky Vista University, 8401 S Chambers Road, Parker, CO, 80112, United States, 1 9253236431.
College of Osteopathic Medicine, Rocky Vista University, Ivins, UT, United States.
JMIR Dermatol. 2025 Sep 9;8:e76898. doi: 10.2196/76898.
Dermal fillers have gained increasing popularity for their ability to enhance facial symmetry, restore volume, and improve skin texture. However, their use in patients with cancer undergoing active chemotherapy and radiation therapy poses unique challenges, as these treatments can alter both the safety profile and efficacy of filler procedures. Chemotherapy can interfere with normal wound healing and immune responses, warranting a more cautious and individualized approach when considering dermal fillers in this population. Although rare, dermal fillers have been associated with adverse outcomes in a limited number of diseases, including cellulitis, autoimmune/inflammatory syndrome induced by adjuvants, and a possible predisposition to malignancy. Other effects include localized inflammatory, systemic hypersensitivity, and delayed granulomatous formation, and these could be more severe in patients undergoing antineoplastic therapy. Furthermore, chemotherapy is often paired with adjuvant radiation therapy in cancer treatment, making it important to note the potential changes radiation can have on the skin. More research is needed to examine the direct interactions of chemotherapy and radiation on various filler materials injected within the skin, and how these can alter one's risk of adverse effects. The lack of research on this topic further emphasizes that clinicians should thoroughly educate patients receiving chemotherapy and adjuvant radiation treatment about the heightened potential risks associated with dermal filler injections and treatment regimens should be planned accordingly to minimize any adverse events.
真皮填充剂因其能够增强面部对称性、恢复容积和改善皮肤质地而越来越受欢迎。然而，在接受积极化疗和放疗的癌症患者中使用真皮填充剂带来了独特的挑战，因为这些治疗会改变填充手术的安全性和疗效。化疗会干扰正常的伤口愈合和免疫反应，因此在考虑为这类人群使用真皮填充剂时需要采取更谨慎和个性化的方法。尽管罕见，但真皮填充剂在少数疾病中已与不良后果相关，包括蜂窝织炎、佐剂诱导的自身免疫/炎症综合征以及可能的恶性肿瘤易感性。其他影响包括局部炎症、全身过敏反应和延迟性肉芽肿形成，而这些在接受抗肿瘤治疗的患者中可能更严重。此外，在癌症治疗中化疗常与辅助放疗联合使用，因此需要注意放疗对皮肤可能产生的变化。需要更多研究来考察化疗和放疗对注入皮肤内的各种填充材料的直接相互作用，以及这些相互作用如何改变不良反应的风险。关于这一主题的研究不足进一步强调，临床医生应充分告知接受化疗和辅助放疗的患者真皮填充剂注射相关的潜在高风险，并且应相应制定治疗方案以尽量减少任何不良事件。
