Huang Bo, Zhang Xinxin, Guo Hongbao, Meng Cheng, Cui Jingqiu, Jia Junya
Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
Department of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.
Ren Fail. 2025 Dec;47(1):2555375. doi: 10.1080/0886022X.2025.2555375. Epub 2025 Sep 9.
This study aimed to investigate the association between body roundness index (BRI) and deaths from all causes and cardiovascular disease (CVD) in participants with chronic kidney disease (CKD).
The data was sourced from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. Cox proportional hazards regression along with restricted cubic splines were applied to assess the associations of BRI with deaths from all causes and CVD in individuals with CKD.
In total, 8,000 individuals were included in the final analysis. In participants with CKD, there was a nonlinear U-shaped association between BRI and deaths from all causes and CVD, with inflection points at 6.29 and 6.04. When BRI was below the inflection points, each unit increment of BRI correlated with a 11% reduction in deaths from all causes [HR: 0.89 (0.84-0.94), < 0.001] and a 15% reduction in deaths from CVD [HR: 0.85 (0.75-0.95), = 0.006)]. Conversely, when BRI surpassed the inflection points, each unit increment of BRI was linked to a 9% rise in deaths from all causes [HR: 1.09 (1.03-1.14), = 0.001] and a 10% rise in deaths from CVD [HR: 1.10 (1.02-1.20), = 0.019].
In this nationally representative study, we found a nonlinear U-shaped association between BRI and deaths from all causes and CVD among participants with CKD, with inflection points at 6.29 and 6.04. Further research is required to establish the optimal range of BRI as a measure of visceral fat deposition.
本研究旨在调查慢性肾脏病（CKD）患者的身体圆润度指数（BRI）与全因死亡及心血管疾病（CVD）死亡之间的关联。
数据来源于1999 - 2018年美国国家健康与营养检查调查（NHANES）。采用Cox比例风险回归及受限立方样条来评估CKD个体中BRI与全因死亡及CVD死亡之间的关联。
最终分析共纳入8000名个体。在CKD患者中，BRI与全因死亡及CVD死亡之间存在非线性U型关联，拐点分别为6.29和6.04。当BRI低于拐点时，BRI每增加一个单位与全因死亡降低11%相关[风险比（HR）：0.89（0.84 - 0.94），P < 0.001]，与CVD死亡降低15%相关[HR：0.85（0.75 - 0.95），P = 0.006]。相反，当BRI超过拐点时，BRI每增加一个单位与全因死亡增加9%相关[HR：1.09（1.03 - 1.14），P = 0.001]，与CVD死亡增加10%相关[HR：1.10（1.02 - 1.20），P = 0.019]。
在这项具有全国代表性的研究中，我们发现CKD患者中BRI与全因死亡及CVD死亡之间存在非线性U型关联，拐点分别为6.29和6.04。需要进一步研究以确定作为内脏脂肪沉积指标的BRI的最佳范围。
