下一代尿液替诺福韦侧向流动分析法用于抗逆转录病毒治疗依从性监测时是否需要特定性别的临界值？
Are Sex-Specific Cutoffs Needed With a Next-Generation Urine Tenofovir Lateral Flow Assay for Antiretroviral Adherence Monitoring?
作者信息
Niu Xin, Sevenler Derin, Dossantos Sandy, Toner Mehmet, Sandlin Rebecca, Siriprakaisil Oraphan, Sukrakanchana Pra-Ornsuda, Cressey Tim R, Drain Paul K
机构信息
Department of Epidemiology, University of Washington, Seattle, Washington, USA.
International Clinical Research Center, Department of Global Health, University of Washington, Seattle, Washington, USA.
出版信息
Open Forum Infect Dis. 2025 Aug 21;12(9):ofaf512. doi: 10.1093/ofid/ofaf512. eCollection 2025 Sep.
Abstract
Accurate point-of-care tools are needed to detect early nonadherence to daily HIV regimens and support timely transitions to long-acting options. Emerging evidence suggests that females may require higher adherence than males to achieve equivalent protection. Our next-generation urine tenofovir assay showed high accuracy across sexes but lower urine drug levels among female participants.
摘要
需要精确的即时检测工具来发现早期对每日抗艾滋病毒治疗方案的不依从情况，并支持及时过渡到长效治疗方案。新出现的证据表明，女性可能需要比男性更高的依从性才能获得同等的保护。我们的新一代尿替诺福韦检测在不同性别中都显示出很高的准确性，但女性参与者的尿液药物水平较低。
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本文引用的文献
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