菲律宾脊髓灰质炎病毒爆发期间对免疫缺陷相关疫苗衍生脊髓灰质炎病毒的公共卫生应对：病例报告
Public health response to immunodeficiency-related vaccine-derived poliovirus during a poliovirus outbreak in the Philippines: a case report.
作者信息
Co Krizia Joy A, Tarnate Paul Sherwin O, Castor Mary Anne R, Ong-Lim Anna Lisa T
机构信息
Division of Infectious and Tropical Diseases in Pediatrics, Department of Pediatrics, College of Medicine - Philippine General Hospital, University of the Philippines, Manila, Philippines.
Division of Allergy and Immunology, Department of Pediatrics, College of Medicine - Philippine General Hospital, University of the Philippines, Manila, Philippines.
出版信息
IJID Reg. 2025 Aug 7;16:100722. doi: 10.1016/j.ijregi.2025.100722. eCollection 2025 Sep.
Abstract
Immunodeficiency-related vaccine-derived poliovirus (iVDPV) was detected in the stool of a 5-year-old male patient with combined immunodeficiency. The patient presented in August 2019 with chronic diarrhea, fever, and generalized weakness. This case was identified concurrently with the 2019-2020 poliovirus outbreak in the Philippines. Antiviral therapy with pocapavir and remdesivir was administered but was unsuccessful in iVDPV clearance. The patient remained a chronic iVDPV excretor until his death in 2023.
摘要
在一名患有联合免疫缺陷的5岁男性患者的粪便中检测到免疫缺陷相关的疫苗衍生脊髓灰质炎病毒（iVDPV）。该患者于2019年8月出现慢性腹泻、发热和全身无力症状。此病例与2019 - 2020年菲律宾脊髓灰质炎病毒疫情同时被发现。给予了泊卡韦和瑞德西韦进行抗病毒治疗，但未能清除iVDPV。该患者一直是慢性iVDPV排泄者，直至2023年去世。
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