Agyekum Merlene A, Nguah Samuel B, Attakorah Joseph, Nettey Gustav K, Oppong Kwaku G, Paintsil Vivian, Akoto Alex O, Buabeng Kwame O
Department of Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Ghana Med J. 2024 Jun;58(2):117-123. doi: 10.4314/gmj.v58i2.2.
To measure the adherence to routinely prescribed medications among Sickle Cell Disease (SCD) patients in Kumasi, Ghana.
A cohort study involving paediatric SCD patients presenting to the outpatient clinic at the Komfo Anokye Teaching Hospital (KATH).
The Pediatric SCD Outpatient Clinic of KATH.
Two hundred SCD patients visiting the outpatient clinic.
None.
Cost and adherence to Penicillin V, Folic Acid, Hydroxyurea and Vitamins prescribed to SCD patients on routine outpatient visits.
Of the 200 participants, the highest and lowest phenotypes were Hb-SS (162, 80.1%) and Sβ-thal (3, 1.5%), respectively. The adherence rate to routine medications was 13.5% (95%CI: ut9.1% to 19.0%). Patient factors that affect adherence included forgetfulness 98(49%), cost 54(27%), and side effects 28(14%) of medication, and improvement in health 7(3.5%). Hydroxyurea was the costliest to the patients with a median (IQR) cost of GHc 75 (0, 450) or USD12 (0, 73), and the least was folic acid with a median of GHc 6 (0, 42) or USD 1 (0, 7). 44.5% of all medications prescribed were not obtained in full. 83% of those who did not purchase all the medicines attributed this to cost, with 13% indicating they had some at home.
There is low adherence to routine medications used by SCD patients in Kumasi, and this could be because of their relatively high cost. Further studies should be made to assess the non-adherent effects of SCD medications on patients' health.
This work was funded by the Sickle Pan-African Research Consortium (SPARCO), Kumasi-Ghana site.
测定加纳库马西镰状细胞病（SCD）患者对常规处方药的依从性。
一项队列研究，涉及到Komfo Anokye教学医院（KATH）门诊就诊的儿科SCD患者。
KATH的儿科SCD门诊。
200名到门诊就诊的SCD患者。
无。
SCD患者常规门诊就诊时，青霉素V、叶酸、羟基脲和维生素的费用及依从性。
200名参与者中，最高和最低表型分别为Hb-SS（162例，80.1%）和Sβ-地中海贫血（3例，1.5%）。常规药物的依从率为13.5%（95%CI：9.1%至19.0%）。影响依从性的患者因素包括健忘98例（49%）、费用54例（27%）、药物副作用28例（14%）以及健康状况改善7例（3.5%）。羟基脲对患者来说成本最高，中位数（IQR）成本为75加纳塞地（0，450）或12美元（0，73），成本最低的是叶酸，中位数为6加纳塞地（0，42）或1美元（0，7）。所有处方药物中有44.5%未全部获取。83%未购买所有药物的患者将此归因于费用，13%表示家中有部分药物。
库马西SCD患者对常规药物的依从性较低，这可能是因为其成本相对较高。应进一步开展研究，以评估SCD药物不依从对患者健康的影响。
本研究由镰状细胞泛非研究联盟（SPARCO）加纳库马西站点资助。
