Sachu Arun, Sunny Sanjo, Mathew Philip, Kumar Ajeesh, David Alice
Department of Microbiology, Believers Church Medical College Hospital, Thiruvalla, Kerala, India.
Department of Critical Care, Believers Church Medical College, Thiruvalla, Kerala, India.
Ghana Med J. 2024 Jun;58(2):156-164. doi: 10.4314/gmj.v58i2.7.
To determine the proportion of patients admitted to ICU who are colonised with carbapenem-resistant Enterobacteriaceae (CRE) and to estimate the agreement between colonised patients and patients who developed an infection with CRE.
Prospective surveillance study.
The ICU of a tertiary care hospital in Kerala, India.
All patients above 18 were admitted to the ICU during the study period.
Patients colonised with CRE and systemic infection with the colonised organism.
CRE colonisation was found in 20(8.7%) samples. Among the 20 patients in the study who were colonised with CRE, 5(25%) developed systemic infection due to CRE. History of antibiotic usage and admission to other hospitals in the last 90 days were independent predictors of CRE colonisation.
Five of the 20 patients colonised with CRE developed an infection. Hospital admission and antibiotic usage were the main risk factors associated with CRE colonisation. Antibiotic escalation was suggested for two colonised patients based on their clinical worsening, but they succumbed to the illness. This study led us to modify our infection control practices, which led to isolating patients colonised with CRE.
None declared.
确定入住重症监护病房（ICU）且被耐碳青霉烯类肠杆菌科细菌（CRE）定植的患者比例，并评估定植患者与发生CRE感染患者之间的一致性。
前瞻性监测研究。
印度喀拉拉邦一家三级护理医院的ICU。
研究期间所有18岁以上入住ICU的患者。
被CRE定植的患者以及定植菌引起的全身感染。
在20份（8.7%）样本中发现了CRE定植。在研究中被CRE定植的20名患者中，有5名（25%）因CRE发生了全身感染。抗生素使用史和过去90天内入住其他医院是CRE定植的独立预测因素。
20名被CRE定植的患者中有5名发生了感染。住院和抗生素使用是与CRE定植相关的主要危险因素。根据两名定植患者的临床病情恶化情况，建议升级抗生素治疗，但他们最终因病死亡。这项研究促使我们修改了感染控制措施，对被CRE定植的患者进行隔离。
未声明。
