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氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描在一例罕见的广泛皮肤和骨骼受累的厄尔德海姆-切斯特病中的应用

F FDG PET/CT in a Rare Case of Erdheim-Chester Disease with Extensive Cutaneous and Skeletal Involvement.

作者信息

Prakash Anjali, Santhamma Shagos Gopalan, Ashwini C, Charles Deepak, Thomas Joe

机构信息

Department of Nuclear Medicine and Molecular Imaging, Aster Medcity, Kochi, Kerala, India.

Department of Haematology and Haemato-Oncology, Aster Medcity, Kochi, Kerala, India.

出版信息

Indian J Nucl Med. 2025 May-Jun;40(3):176-177. doi: 10.4103/ijnm.ijnm_153_24. Epub 2025 Aug 7.

DOI:10.4103/ijnm.ijnm_153_24
PMID:40927149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12416591/
Abstract

Erdheim-Chester disease (ECD) is a rare systemic non-Langerhans cell histiocytosis with multiple organ involvement. Being a rare disease with variable clinical manifestations, it is often difficult to diagnose. F-2-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) plays a vital role in assessing disease extent and severity, diagnosis, treatment response and is a potential biomarker for BRAF mutation. We present here a rare case of ECD with FDG PET/CT showing extensive cutaneous lesions apart from skeletal involvement.

摘要

厄尔德海姆-切斯特病（ECD）是一种罕见的系统性非朗格汉斯细胞组织细胞增多症，可累及多个器官。作为一种临床表现多样的罕见疾病，其诊断往往具有挑战性。F-2-氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）在评估疾病范围和严重程度、诊断、治疗反应方面起着至关重要的作用，并且是BRAF突变的潜在生物标志物。我们在此报告一例罕见的ECD病例，FDG PET/CT显示除骨骼受累外，还有广泛的皮肤病变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87e/12416591/2bfe153537c1/IJNM-40-176-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87e/12416591/2bfe153537c1/IJNM-40-176-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87e/12416591/2bfe153537c1/IJNM-40-176-g001.jpg

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本文引用的文献

1
F-FDG PET/CT in Erdheim-Chester Disease: Imaging Findings and Potential BRAF Mutation Biomarker.FDG PET/CT 在 Erdheim-Chester 病中的应用：影像学表现与潜在 BRAF 基因突变生物标志物。
J Nucl Med. 2018 May;59(5):774-779. doi: 10.2967/jnumed.117.200741. Epub 2017 Nov 2.
2
Thoracic, abdominal and musculoskeletal involvement in Erdheim-Chester disease: CT, MR and PET imaging findings. Erdheim-Chester 病的胸部、腹部和肌肉骨骼累及：CT、MR 和 PET 成像表现。
Insights Imaging. 2014 Aug;5(4):473-82. doi: 10.1007/s13244-014-0331-7. Epub 2014 Jul 14.
3
Erdheim-Chester Disease: a comprehensive review of the literature.
厄德海姆-切斯特病：文献综述。
Orphanet J Rare Dis. 2013 Sep 8;8:137. doi: 10.1186/1750-1172-8-137.