Korppas Miro, Tiihonen Miia, Buch Lund Marika, Kvarnström Kirsi
School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
HUS Pharmacy, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Basic Clin Pharmacol Toxicol. 2025 Oct;137(4):e70106. doi: 10.1111/bcpt.70106.
While deprescribing benzodiazepines and related drugs (BZRDs) is crucial for preventing prolonged use and their associated adverse effects, it presents challenges from a healthcare perspective, because of limited resources and time. Recently, a pharmacist-led deprescribing of BZRDs in the treatment of insomnia was introduced in Helsinki's primary care health centres. To explore pharmacists' and physicians' insights, qualitative semi-structured interviews were conducted via Microsoft Teams with physicians and pharmacists involved in a pharmacist-led deprescribing. The interviews were recorded, transcribed verbatim and analysed abductively. A total of four pharmacists and four physicians from four health centres participated in this study. Pharmacist-led deprescribing was perceived as having positive outcomes and as being efficient, particularly in saving physicians' time and resources. Various patient-related facilitators and barriers were identified, with patient motivation and willingness being the most cited. Suggestions for improvement included establishing clear criteria for deprescribing, clarifying the roles in the process flow, providing enhanced deprescribing guidance and educational materials and enhancing the patient-centred approach by actively involving patients in the decision-making process and considering the patient's overall situation. Overall, the pharmacist-led model was seen as a promising and resource-efficient approach to deprescribing BZRDs in primary care health centres.
虽然停用苯二氮䓬类及相关药物（BZRDs）对于预防长期使用及其相关不良反应至关重要，但从医疗保健角度来看，由于资源和时间有限，这带来了挑战。最近，赫尔辛基的初级保健健康中心引入了由药剂师主导的停用BZRDs治疗失眠的方法。为了探究药剂师和医生的见解，通过微软团队对参与药剂师主导的停药过程的医生和药剂师进行了定性半结构化访谈。访谈进行了录音，逐字转录并进行归纳分析。来自四个健康中心的总共四名药剂师和四名医生参与了这项研究。药剂师主导的停药被认为具有积极效果且效率高，特别是在节省医生的时间和资源方面。确定了各种与患者相关的促进因素和障碍，其中患者的积极性和意愿被提及最多。改进建议包括制定明确的停药标准，明确流程中的角色，提供强化的停药指导和教育材料，以及通过让患者积极参与决策过程并考虑患者的整体情况来加强以患者为中心的方法。总体而言，药剂师主导的模式被视为在初级保健健康中心停用BZRDs的一种有前景且资源高效的方法。
