Henry K R
Dev Psychobiol. 1985 Nov;18(6):461-6. doi: 10.1002/dev.420180603.
Innate susceptibility to audiogenic seizures develops and declines at varying rates and ages, depending upon genotype and environmental conditions. Auditory dysfunctions have been experimentally produced which induce susceptibility in otherwise nonsusceptible mouse strains. In order to more closely correlate cochlear functions and audiogenic seizures in genetically susceptible mice, both measures were obtained from LP/J mice, at ages ranging from 8 to 120 days. Susceptibility to sound-produced convulsions was first noted at 12 days, was maximal from 18 to 32 days, declined rapidly by 40 days, and disappeared by 120 days of age. Cochlear nerve-evoked potential thresholds were very high at 12 days, were lowest between 18 and 32 days and increased thereafter. The correlation between susceptibility and cochlear thresholds was greatest for high frequencies (r = -.93), intermediate for midfrequency (r = -.77), and poorest for low frequencies (r = -.56). It was concluded that either genetic or environmental factors which produce an intermediate level of high frequency cochlear damage in the young mouse will produce susceptibility to audiogenic seizures.
对听源性癫痫发作的先天易感性会以不同的速率在不同年龄阶段发展和下降，这取决于基因型和环境条件。实验诱导出了听觉功能障碍，使原本不易感的小鼠品系产生了易感性。为了更紧密地关联基因易感性小鼠的耳蜗功能和听源性癫痫发作，对8至120日龄的LP/J小鼠同时进行了这两项测量。对声音诱发惊厥的易感性在12日龄时首次被发现，在18至32日龄时达到最大值，40日龄时迅速下降，到120日龄时消失。耳蜗神经诱发电位阈值在12日龄时非常高，在18至32日龄之间最低，此后升高。易感性与耳蜗阈值之间的相关性在高频时最大（r = -0.93），中频时中等（r = -0.77），低频时最差（r = -0.56）。得出的结论是，在幼鼠中产生中等程度高频耳蜗损伤的遗传或环境因素会导致对听源性癫痫发作的易感性。
