Zha Jinhui, Cang Pengxu, Zhong Yonghao, Liu Ruilin, Fan Gang
Shenzhen University Sixth Affiliated Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Hunan Cancer Hospital, the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Sci Prog. 2025 Jul-Sep;108(3):368504251368237. doi: 10.1177/00368504251368237. Epub 2025 Sep 10.
Colorectal cancer ranks among the most prevalent and lethal malignant tumors globally. Historically, the incidence of colorectal cancer in China has been lower than that in developed European and American countries; however, recent trends indicate a rising incidence due to changes in dietary patterns and lifestyle. Lipids serve critical roles in human physiology, such as energy provision, cell membrane formation, signaling molecule function, and hormone synthesis. Dysregulation of lipid metabolism is strongly associated with various metabolic disorders, including cardiovascular disease, obesity, hepatic steatosis, and diabetes, as well as tumor initiation, progression, and metastasis. Lipid metabolism significantly contributes to cancer development by facilitating biofilm synthesis, supplying substrates for biomass production, and activating signaling pathways linked to cancer cell proliferation and migration. This narrative review summarizes recent advancements in understanding the regulation of lipid metabolism in colorectal cancer, evaluates potential molecular targets, and highlights relevant clinical trials. All relevant literature was retrieved through a comprehensive search of the PubMed database.
结直肠癌是全球最常见且致命的恶性肿瘤之一。从历史上看，中国结直肠癌的发病率一直低于欧美发达国家；然而，近期趋势表明，由于饮食模式和生活方式的改变，发病率呈上升趋势。脂质在人体生理过程中发挥着关键作用，如提供能量、形成细胞膜、发挥信号分子功能以及合成激素。脂质代谢失调与各种代谢紊乱密切相关，包括心血管疾病、肥胖、肝脂肪变性和糖尿病，以及肿瘤的发生、发展和转移。脂质代谢通过促进生物膜合成、为生物质生产提供底物以及激活与癌细胞增殖和迁移相关的信号通路，对癌症发展有显著贡献。这篇叙述性综述总结了在理解结直肠癌脂质代谢调控方面的最新进展，评估了潜在的分子靶点，并重点介绍了相关的临床试验。所有相关文献均通过全面检索PubMed数据库获得。
