Chen Ting, Wen Sha, Gong Ling, Hou Xianfeng, Dong Lian, Bai Ying, Xu Zucai
Department of Neurology, The Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi 563000, Guizhou, PR China; The Affiliated Jinyang Hospital of Guizhou Medical University, No. 547 Jinyang South Road, Guiyang 550081, Guizhou, PR China; Key Laboratory of Brain Function and Brain Disease Prevention and Treatment of Guizhou Province, Zunyi 563000, Guizhou, PR China.
Department of Neurology, The Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi 563000, Guizhou, PR China.
Neurobiol Dis. 2025 Oct 15;215:107091. doi: 10.1016/j.nbd.2025.107091. Epub 2025 Sep 8.
Lactylation is a novel post-translational modification (PTM) mediated by lactate, which dynamically regulates protein functions and gene expression by covalently attaching lactate groups to lysine residues. Recent studies have shown that abnormal lactate metabolism not only contributes to the pathogenesis of epilepsy through microenvironment acidification but also influences neuroinflammation, energy metabolism imbalance, neurotransmitter dysregulation, synaptic plasticity, and epigenetic regulation via lactylation. This positions lactylation as a critical metabolic-epigenetic intersection in the pathological mechanisms of epilepsy. This review systematically summarizes the molecular mechanisms of lactylation and its potential roles in epilepsy, while exploring intervention strategies targeting lactylation to provide new perspectives for epilepsy treatment.
乳酰化是一种由乳酸介导的新型翻译后修饰（PTM），它通过将乳酸基团共价连接到赖氨酸残基上，动态调节蛋白质功能和基因表达。最近的研究表明，异常的乳酸代谢不仅通过微环境酸化促进癫痫的发病机制，还通过乳酰化影响神经炎症、能量代谢失衡、神经递质失调、突触可塑性和表观遗传调控。这使乳酰化成为癫痫病理机制中一个关键的代谢 - 表观遗传交叉点。本综述系统总结了乳酰化的分子机制及其在癫痫中的潜在作用，同时探索针对乳酰化的干预策略，为癫痫治疗提供新的视角。
