Rossi Esther Diana, Griffith Christopher C
Division of Anatomic Pathology and Histology, Fondazione Policlinico Universitario "Agostino Gemelli"-IRCCS, Rome, Italy.
Associate Professor of Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, USA.
Cancer Cytopathol. 2025 Oct;133(10):e70037. doi: 10.1002/cncy.70037.
The current review article deals with the evaluation of the oncocytic/oncocytoid lesions in the salivary gland. The authors will focus on the diagnosis of Warthin tumor (WT) as a launching point to detail important morphologic findings that should prompt designation of an aspirate as oncocytic salivary gland neoplasm of uncertain malignant potential or other Milan categories. Oncocytic cells are defined as cells with a moderate to abundant amount of eosinophilic finely granular cytoplasm, round-to-oval nuclei, and large-distinct nucleoli. In contrast, the term oncocytoid is also frequently used in this discussion and indicates tumor cells with similarly abundant and sometimes granular cytoplasm but lacking all the definitive features of a true oncocyte. Several helpful tips are provided in hopes of improving an accurate diagnosis of WT on an aspirate sample. Using these types allows for consideration of important differential diagnoses, including both benign and malignant entities, when faced with an oncocytic salivary gland neoplasm. The morphological criteria as well as the possible application of ancillary techniques are also discussed.
当前这篇综述文章探讨了唾液腺嗜酸性/嗜酸性样病变的评估。作者将把沃辛瘤（WT）的诊断作为切入点，详细阐述重要的形态学发现，这些发现应促使将抽吸物诊断为具有不确定恶性潜能的嗜酸性唾液腺肿瘤或其他米兰分类。嗜酸性细胞被定义为具有中等至丰富嗜酸性细颗粒细胞质、圆形至椭圆形细胞核以及明显大核仁的细胞。相比之下，“嗜酸性样”一词在本讨论中也经常使用，它表示具有同样丰富且有时呈颗粒状细胞质但缺乏真正嗜酸性细胞所有明确特征的肿瘤细胞。文中提供了一些有用的提示，希望能提高对抽吸样本中WT的准确诊断。当面对嗜酸性唾液腺肿瘤时，使用这些类型有助于考虑重要的鉴别诊断，包括良性和恶性实体。还讨论了形态学标准以及辅助技术的可能应用。
