Subhadarsanee Dr Chitrika, Dhadse Dr Prasad, Bajaj Dr Pavan, Chimote Dr Mosami, Sethiya Dr Kiran, Bhombe Dr Komal, Hassan Dr Safiya, Oza Dr Ranu
Assistant Professor, Department of Periodontics, Sharad Pawar Dental College., Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, 442001, India.
Professor and HOD, Department of Periodontics, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, 442001, India.
F1000Res. 2023 Oct 20;12:1387. doi: 10.12688/f1000research.131974.1. eCollection 2023.
The aim of the study was to compare the effectiveness of platelet rich fibrin matrix (PRFM) membrane with collagen membrane (Colo Gide) in combination with demineralized freeze-dried bone allograft (DFDBA) in the treatment of mandibular Class II furcation defects. This randomized, parallel designed, controlled, clinical investigation was conducted in 24 subjects (15 male and 9 female) having Class II furcation defects either buccally or lingually. The test group was treated with DFDBA and PRFM membrane while the control group was treated with DFDBA and collagen membrane. The clinical measurements such as plaque index (PI), papillary bleeding index (PBI), pocket probing depth (PPD), relative attachment level (R-CAL) and relative gingival marginal level (R-GML) were measured at baseline and six months. Radiographic parameters, such as vertical defect depth (VDD), horizontal defect depth (HDD) and defect width (DW) were measured using cone beam computed tomography taken at baseline, three and six months. Student's paired t-test was utilized to analyse data from the day of surgery to six months. A comparison of both groups at baseline and six months was achieved by student's unpaired t-test. 10 sites in test group (83.33%) showed the advancement from class II to class I compared to eight sites in control (66.66%). Remaining defects in test group n=2 (16.66%) and control group n=4 (33.33%) showed marked reduction in horizontal defect depth compared to baseline. No complete closure of the defect was seen in either group. When treating class II furcation defects, the use of PRFM membrane combined with DFDBA seems to be advantages with regards to collagen membrane. The presented set up seems feasible with regards to randomization, acceptance, retention and achievement of satisfactory outcomes.
本研究的目的是比较富含血小板纤维蛋白基质（PRFM）膜与胶原膜（Colo Gide）联合脱矿冻干骨同种异体移植（DFDBA）治疗下颌Ⅱ度根分叉病变的有效性。这项随机、平行设计、对照的临床研究在24名受试者（15名男性和9名女性）中进行，这些受试者存在颊侧或舌侧的Ⅱ度根分叉病变。试验组接受DFDBA和PRFM膜治疗，而对照组接受DFDBA和胶原膜治疗。在基线和6个月时测量临床指标，如菌斑指数（PI）、龈乳头出血指数（PBI）、牙周袋探诊深度（PPD）、相对附着水平（R-CAL）和相对牙龈边缘水平（R-GML）。使用在基线、3个月和6个月时拍摄的锥形束计算机断层扫描测量影像学参数，如垂直缺损深度（VDD）、水平缺损深度（HDD）和缺损宽度（DW）。采用学生配对t检验分析从手术当天到6个月的数据。通过学生非配对t检验对两组在基线和6个月时进行比较。试验组10个部位（83.33%）显示从Ⅱ度进展到Ⅰ度，而对照组8个部位（66.66%）有此进展。试验组其余n = 2个部位（16.66%）和对照组其余n = 4个部位（33.33%）与基线相比，水平缺损深度显著降低。两组均未观察到缺损完全闭合。在治疗Ⅱ度根分叉病变时，PRFM膜联合DFDBA的使用相对于胶原膜似乎具有优势。所呈现的设置在随机化、接受度、保留率和取得满意结果方面似乎是可行的。
