缓释对健康受试者中茶碱药代动力学的影响。

Effect of sustained-release on the pharmacokinetics of theophylline in healthy subjects.

作者信息

Bialer M, Salame K, Raz I

出版信息

Int J Clin Pharmacol Ther Toxicol. 1985 Dec;23(12):662-7.

Abstract

The effect of sustained-release on the pharmacokinetics of theophylline was examined by comparing two sustained-release formulations (Theo-Dur and Theotard) to an oral solution and i.v. preparation of the drug. Drug-level monitoring was performed by an HPLC assay. The absorption profiles of the three oral formulations were pharmacokinetically analyzed by using the Loo-Riegelman procedure. The absorption of theophylline after the administration of the Theo-Dur and Theotard was found to be of an apparent zero-order kinetics.

摘要

通过将两种缓释制剂（茶喘平（Theo-Dur）和茶喘宁（Theotard））与该药物的口服溶液和静脉注射制剂进行比较，研究了缓释对茶碱药代动力学的影响。通过高效液相色谱法进行药物水平监测。使用Loo-Riegelman方法对三种口服制剂的吸收曲线进行药代动力学分析。发现服用茶喘平（Theo-Dur）和茶喘宁（Theotard）后茶碱的吸收呈明显的零级动力学。