Hamdan Saif A, Nassur Jamie A, Thornton Sarah
Department of Neuro-ophthalmology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Am J Ophthalmol Case Rep. 2025 Aug 20;39:102409. doi: 10.1016/j.ajoc.2025.102409. eCollection 2025 Sep.
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) has recently been distinguished as its own disease entity separate from other demyelinating diseases. This case report highlights the possible association of orbital trauma with the development of MOG antibody (MOG-IgG) optic neuritis.
A 31-year-old male with no significant ocular history presented with blurry vision in the right eye four weeks after a motorcycle crash. Right eye examination was notable for a significant decrease in visual acuity with a relative afferent pupillary defect and circumferential disc elevation on fundoscopy. An extensive workup, including imaging and serology, revealed optic neuritis with a positive MOG-IgG antibody titer. The patient was treated with intravenous steroids followed by an oral taper, with near-complete resolution of his symptoms.
MOG antibody-related optic neuritis should be considered in patients presenting with painful vision loss after trauma, as early recognition and treatment can lead to favorable outcomes.
髓鞘少突胶质细胞糖蛋白（MOG）抗体相关疾病（MOGAD）最近已被确认为一种独立于其他脱髓鞘疾病的疾病实体。本病例报告强调了眼眶外伤与MOG抗体（MOG-IgG）视神经炎发生之间可能存在的关联。
一名31岁男性，无明显眼部病史，在摩托车事故四周后出现右眼视力模糊。右眼检查显示视力显著下降，伴有相对传入性瞳孔障碍，眼底镜检查可见视盘环形隆起。包括影像学和血清学在内的全面检查显示为视神经炎，MOG-IgG抗体滴度呈阳性。患者接受了静脉注射类固醇治疗，随后口服逐渐减量，症状几乎完全缓解。
对于外伤后出现视力丧失伴疼痛的患者，应考虑MOG抗体相关视神经炎，因为早期识别和治疗可带来良好预后。
