Safdari Yaghoub
Golestan Research Center of Gastroenterology and Hepatology Golestan University of Medical Sciences Gorgan Iran.
Clin Case Rep. 2025 Sep 8;13(9):e70880. doi: 10.1002/ccr3.70880. eCollection 2025 Sep.
Brucellosis is a bacterial infection with a wide spectrum of clinical manifestations, yet endocrine complications such as primary hypogonadism and gynecomastia are exceedingly rare. We present the case of a 60-year-old male who was treated for brucellosis and, several weeks after discharge, developed unilateral enlargement of the left breast. Laboratory evaluation revealed significantly elevated gonadotropins (FSH and LH) with markedly decreased serum testosterone levels, indicating primary testicular failure. Sonographic imaging confirmed gynecomastia with a flame-shaped, irregular mass. This case highlights a rare hormonal sequela of brucellosis and emphasizes the importance of endocrine evaluation in patients who present with atypical manifestations following systemic infections.
布鲁氏菌病是一种具有广泛临床表现的细菌感染，但原发性性腺功能减退和男性乳房发育等内分泌并发症极为罕见。我们报告一例60岁男性，他接受了布鲁氏菌病治疗，出院几周后出现左侧乳房单侧肿大。实验室检查显示促性腺激素（FSH和LH）显著升高，血清睾酮水平明显降低，提示原发性睾丸功能衰竭。超声成像证实为男性乳房发育，伴有火焰状不规则肿块。该病例突出了布鲁氏菌病罕见的激素后遗症，并强调了对全身感染后出现非典型表现的患者进行内分泌评估的重要性。
