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超越过敏反应:新冠病毒引发的假性血管性水肿被忽视的法医复杂性

Beyond Anaphylaxis: The Overlooked Forensic Complexity of COVID-19-Triggered Pseudoangioedema.

作者信息

Aban Jomar L, Lucero-Prisno Don Eliseo, Ogaya Jerico Bautista, Ong Christian Joseph N

机构信息

Secondary Education Department, College of Education, North La Union Campus, Don Mariano Marcos Memorial State University, Bacnotan, La Union, PhilippinesRoles: A, B, C, D, E, 1.

Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UKRoles: D, E, 4, 5, 6.

出版信息

Acad Forensic Pathol. 2025 Sep 8:19253621251374276. doi: 10.1177/19253621251374276.

DOI:10.1177/19253621251374276
PMID:40933539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12417447/
Abstract

Gray et al's investigation into angioedema-anaphylaxis deaths amidst the COVID-19 pandemic raises important forensic implications, particularly concerning differential diagnostics in postmortem settings ( 1). However, a critical avenue requiring deeper contextualization is the immunopathological intersection between SARS-CoV-2-induced mast cell activation and bradykinin-mediated pathways ( 2).

摘要

格雷等人对新冠疫情期间血管性水肿-过敏反应死亡病例的调查引发了重要的法医学问题,尤其是在尸检环境中的鉴别诊断方面(1)。然而,一个需要更深入背景化的关键领域是严重急性呼吸综合征冠状病毒2(SARS-CoV-2)诱导的肥大细胞活化与缓激肽介导的途径之间的免疫病理学交叉点(2)。

相似文献

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Beyond Anaphylaxis: The Overlooked Forensic Complexity of COVID-19-Triggered Pseudoangioedema.超越过敏反应:新冠病毒引发的假性血管性水肿被忽视的法医复杂性
Acad Forensic Pathol. 2025 Sep 8:19253621251374276. doi: 10.1177/19253621251374276.
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Beyond the numbers: Critical analysis of the role of postmortem tryptase in the forensic diagnosis of anaphylaxis.数字之外:对尸检组织蛋白酶在过敏反应法医诊断中作用的批判性分析
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J Allergy Clin Immunol Pract. 2021 Oct;9(10):3546-3567. doi: 10.1016/j.jaip.2021.06.006. Epub 2021 Jun 18.

本文引用的文献

1
Case Report: Two cases of hereditary angioedema in a Chinese family.病例报告:一个中国家庭中的两例遗传性血管性水肿。
Front Allergy. 2025 Jun 2;6:1587904. doi: 10.3389/falgy.2025.1587904. eCollection 2025.
2
Deaths from Angioedema-Anaphylaxis and Covid-19.血管性水肿-过敏反应和新冠病毒感染所致死亡
Acad Forensic Pathol. 2025 Feb 21:19253621251320212. doi: 10.1177/19253621251320212.
3
Angioedema Due to Acquired C1-Inhibitor Deficiency Without Hematological Condition: A Multicenter French Cohort Study of 34 Patients.无血液系统疾病的获得性C1抑制物缺乏所致血管性水肿:一项对34例患者的法国多中心队列研究
J Allergy Clin Immunol Pract. 2025 Mar;13(3):542-550.e2. doi: 10.1016/j.jaip.2024.12.027. Epub 2025 Jan 3.
4
Pathophysiology of bradykinin and histamine mediated angioedema.缓激肽和组胺介导的血管性水肿的病理生理学
Front Allergy. 2023 Oct 18;4:1263432. doi: 10.3389/falgy.2023.1263432. eCollection 2023.
5
A scoping review of the pathophysiology of COVID-19.COVID-19 病理生理学的范围性综述。
Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211048026. doi: 10.1177/20587384211048026.
6
Histamine and tryptase levels in patients with acute allergic reactions: An emergency department-based study.急性过敏反应患者的组胺和类胰蛋白酶水平:一项基于急诊科的研究。
J Allergy Clin Immunol. 2000 Jul;106(1 Pt 1):65-71. doi: 10.1067/mai.2000.107600.