Wang Guessy C, Hix Jeremy M L, Tavelli Lorenzo, Yang Yang
Harvard T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Boston, United States.
Department of Radiology and Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr, East Lansing, United States.
Proc SPIE Int Soc Opt Eng. 2023 Feb;12468. doi: 10.1117/12.2653348. Epub 2023 Apr 10.
Photoacoustic imaging is an emerging preclinical modality that uses a combination of optics and acoustics mechanisms to visualize differences in optical absorption in target imaging objects. Photoacoustic imaging is potentially suitable for visualizing vasculature, as the hemoglobin in red blood cells is a prominent heat absorber and therefore serves as a great biomarker. Due to acoustic reflection, diffraction and scattering, photoacoustic imaging is subject to artifacts when the target soft tissue is close to bone. We construct an phantom featuring vascularized soft tissue near long bone, to facilitate evaluation of photoacoustic images and to enable future research on artifact removal in photoacoustic imaging.
光声成像是一种新兴的临床前成像模式，它利用光学和声学机制的组合来可视化目标成像对象中光吸收的差异。光声成像可能适用于血管成像，因为红细胞中的血红蛋白是一种显著的热吸收体，因此是一种很好的生物标志物。由于声反射、衍射和散射，当目标软组织靠近骨骼时，光声成像会产生伪影。我们构建了一个在长骨附近具有血管化软组织的体模，以促进光声图像的评估，并为未来光声成像中的伪影去除研究提供条件。
