Gu Feixue, Zhao Kaiyue, Yan Hengshuo, Sui Dongxin
The Second Clinical College, Shandong University, Jinan 250033, China.
Department of Respiratory Medicine, Second Hospital of Shandong University, Jinan 250033, China.
Zhongguo Fei Ai Za Zhi. 2025 Jul 20;28(7):513-520. doi: 10.3779/j.issn.1009-3419.2025.106.17.
Small cell lung cancer (SCLC), a highly aggressive subtype of lung cancer that originates from pulmonary neuroendocrine cells, accounts for 10% to 15% of all lung cancers. It is characterized by a high rate of early metastasis and extremely poor prognosis, often accompanied by challenges such as drug resistance and recurrence. Related researches indicates that the Notch signaling pathway plays a crucial role in the occurrence and development of SCLC by regulating processes such as cell proliferation, differentiation, and apoptosis. In SCLC, abnormal Notch signaling may promote tumor malignancy and the occurrence of drug resistance. Additionally, the Notch pathway is involved in the epithelial-mesenchymal transition of SCLC and influences immune escape mechanisms through interactions with the tumor immune microenvironment. This article reviews the molecular mechanisms of Notch signaling in SCLC, including the roles of its receptors and ligands, signal transduction processes, and its role in tumorigenesis. It also discusses the research progress of Notch signaling as a potential therapeutic target and looks forward to future research directions in this field. .
小细胞肺癌（SCLC）是一种起源于肺神经内分泌细胞的高度侵袭性肺癌亚型，占所有肺癌的10%至15%。其特点是早期转移率高，预后极差，常伴有耐药性和复发等问题。相关研究表明，Notch信号通路通过调节细胞增殖、分化和凋亡等过程，在SCLC的发生发展中起关键作用。在SCLC中，异常的Notch信号可能促进肿瘤恶性程度和耐药性的发生。此外，Notch通路参与SCLC的上皮-间质转化，并通过与肿瘤免疫微环境的相互作用影响免疫逃逸机制。本文综述了Notch信号在SCLC中的分子机制，包括其受体和配体的作用、信号转导过程及其在肿瘤发生中的作用。还讨论了Notch信号作为潜在治疗靶点的研究进展，并展望了该领域未来的研究方向。
