Vinton Zachary, Wolfe Kevin, MacBride Sean, Heffron Thomas, Jhaveri Vimal, Sotelo Andrea K, Rosenblatt Mark, Kulig Clark, Stotts Matthew
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.
Department of Internal Medicine, Hennepin Health, Minneapolis, MN.
ACG Case Rep J. 2025 Sep 10;12(9):e01827. doi: 10.14309/crj.0000000000001827. eCollection 2025 Sep.
Brucellosis, a zoonotic bacterial infection often characterized by nonspecific symptoms including fever, night sweats, and weight loss, has a prolonged and recurrent course, often leading to chronic symptoms if inadequately treated. Hepatic involvement is well-documented with manifestations ranging from mild hepatitis to hepatic abscesses and granulomas. However, the association of brucellosis with biliary dysplasia or ampullary adenocarcinoma has not been previously reported in medical literature. We present a 68-year-old man with hepatic granulomatosis due to chronic brucellosis complicated by numerous episodes of ascending cholangitis secondary to choledocholithiasis and common bile duct strictures, with high-grade dysplasia and development of ampullary adenocarcinoma.
布鲁氏菌病是一种人畜共患的细菌感染，通常表现为非特异性症状，包括发热、盗汗和体重减轻，病程迁延且易复发，如果治疗不当，常导致慢性症状。肝脏受累有充分记录，表现从轻度肝炎到肝脓肿和肉芽肿不等。然而，布鲁氏菌病与胆管发育异常或壶腹腺癌的关联此前在医学文献中尚未见报道。我们报告一名68岁男性，因慢性布鲁氏菌病导致肝脏肉芽肿，并发胆管结石和胆总管狭窄继发的多次化脓性胆管炎发作，并伴有高级别发育异常和壶腹腺癌形成。
