He Qianqian, Huang Tiantian, Chen Zhihui, Sha Zhou, Wu Haibo
School of Life Sciences, Chongqing University, Chongqing, 401331, China.
Sci China Life Sci. 2025 Sep 8. doi: 10.1007/s11427-024-3037-1.
Coordination between different organelles and metabolic cues is crucial for resistance to pathogen invasion. As the core of maintaining cellular metabolism and homeostasis, mitochondria and lysosomes cooperate in the immune responses and elimination of intracellular pathogens. Previous research has focused on the function of one or the other in isolation, ignoring their pervasive interplay. In this review, we discuss the intricate mechanism of mitochondria-lysosome crosstalk and point out the role of AMP-activated protein kinase (AMPK)-transcription factor EB (TFEB) axis in microbial infections. The crosstalk between mitochondria and lysosomes affects cellular key processes, such as autophagy and programmed death, which play an important role in microbial infections.
不同细胞器与代谢信号之间的协调对于抵抗病原体入侵至关重要。作为维持细胞代谢和内稳态的核心，线粒体和溶酶体在免疫反应及清除细胞内病原体方面相互协作。以往研究多聚焦于二者各自的功能，而忽略了它们之间广泛存在的相互作用。在本综述中，我们探讨了线粒体 - 溶酶体相互作用的复杂机制，并指出AMP激活的蛋白激酶（AMPK）-转录因子EB（TFEB）轴在微生物感染中的作用。线粒体与溶酶体之间的相互作用影响细胞的关键过程，如自噬和程序性死亡，这些过程在微生物感染中发挥着重要作用。
