Unveiling the role of perineural telocytes in mechanosensation, structural insights into their association with herbst and ruffini corpuscles in the quail beak.

This study investigates the structural organization of telocytes (TCs) in the quail beak, focusing on their association with mechanoreceptors like Herbst and Ruffini corpuscles. By exploring these features, the study aim to expand the understanding of TCs' role in mechanosensation and sensory modulation. Paraffin sections stained with Hematoxylin and Eosin revealed TCs surrounding both Herbst and Ruffini corpuscles, as well as nerve fibers. Similar findings observed using Mallory Trichrome staining, which highlighted TCs around these sensory structures. Methylene Blue staining further confirmed the presence of TCs in these areas. Semi-thin sections stained with Toluidine Blue also showed TCs encircling the sensory corpuscles, consistent with other techniques. Transmission electron microscopy (TEM) provided detailed ultrastructural insights, revealing TCs near the Herbst corpuscle, with a prominent nucleus, telopodes, and podoms, while TCs around the Ruffini corpuscle exhibited similar features. These findings have clinical relevance, as TCs increasingly recognized for their role in nerve repair and regeneration. Their involvement in sensory modulation suggests potential therapeutic applications for conditions involving nerve injury or sensory dysfunction. Immunohistochemical analysis of quail beak. Using CD34, VEGF, CD21, and CD68 IHC, TCs observed to form a three-dimensional (3D) network around the nerve. The clinical relevance of these findings was significant, as TCs increasingly recognized for their role in nerve repair and regeneration. Their involvement in sensory modulation suggests potential therapeutic avenues for conditions related to nerve injury or sensory dysfunction. Ongoing research into TCs will further deepen our understanding of their functions in sensory systems and may pave the way for novel treatments for sensory disorders.