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美国东南部和中西部农村医疗服务提供者对将减少伤害策略和暴露前预防(PrEP)处方纳入农村初级保健环境的态度。

Rural providers' attitudes toward integrating harm reduction strategies and PrEP prescribing into rural primary care settings in the US. Southeast and Midwest.

作者信息

Marotta Phillip L, Biaid Miryam, Heimer Robert, Humphries Debbie, Wang Katie, Narayanan Nithya, Lynch Zach, McKay Virginia, Reno Hilary, Winograd Rachel, Goddard-Eckrich Dawn, Filiatreau Lindsey, Stringer Kristi, Backes Kaileigh, Cavazos-Rehg Patricia

机构信息

Brown School, Washington University, St. Louis, MO, USA.

School of Public Health, Washington University, St. Louis, MO, USA.

出版信息

Addict Sci Clin Pract. 2025 Sep 12;20(1):73. doi: 10.1186/s13722-025-00584-9.

Abstract

BACKGROUND

People with opioid use disorders (OUD) living in the South and Midwest are under-prescribed pre-exposure prophylaxis (PrEP) despite an increasing number of providers writing PrEP prescriptions in other regions of the United States. Greater research is needed into attitudes toward integrating harm reduction strategies into primary care and PrEP prescribing among prescribers working in rural primary care settings. The objective of this paper was to examine relationships between providers' attitudes toward buprenorphine and methadone, comprehensive harm reduction (e.g., fentanyl test strips) and self-reported PrEP prescribing in the past year.

METHODS

Relationships were examined between attitudes toward buprenorphine and harm reduction services, and PrEP prescribing among 409 rural primary health care providers (PCPs) treating at least one person with OUD or HIV in several EHE priority states. A Qualtrics panel survey was administered to primary care providers residing in the U.S. South and Midwest and worked in a Federally Qualified Health Center, Rural Health Clinic or other HRSA-eligible health center. Chi-square tests were used to explore significant differences between PrEP prescribers and non-Prescribers on attitudes toward integrating MOUD, drug-related harm reduction into primary care.

RESULTS

Overall, 62.1% (n = 254) of the sample of providers reported writing at least one prescription for PrEP in the past year. Providers who believed that reforming buprenorphine waiver laws made their jobs easier or who expressed interest in integrating naloxone distribution and syringe exchange into primary care were more likely to write prescriptions for PrEP compared to providers who did not have these beliefs. Providers who were from larger facilities and who had specialty training in infectious diseases were more likely to write prescriptions for PrEP.

CONCLUSIONS

Findings from this study suggest that providers who are more open to integrating harm reduction services into primary care are more likely to prescribe PrEP in the past year. PCPs with more positive attitudes toward naloxone, syringe exchange, and buprenorphine were more likely to prescribe PrEP in the past year. Combination interventions may be a promising avenue of reducing the harms of drug use including overdose and HIV infection among populations of people who use drugs.

摘要

背景

尽管在美国其他地区开具暴露前预防(PrEP)处方的医疗服务提供者数量不断增加,但生活在美国南部和中西部的阿片类药物使用障碍(OUD)患者的PrEP处方开具不足。对于在农村初级保健机构工作的开处方者,需要更多地研究他们对将减少伤害策略纳入初级保健和PrEP处方开具的态度。本文的目的是研究医疗服务提供者对丁丙诺啡和美沙酮的态度、全面减少伤害(如芬太尼检测试纸)与过去一年自我报告的PrEP处方开具之间的关系。

方法

研究了在几个EHE优先州治疗至少一名OUD或HIV患者的409名农村初级卫生保健提供者(PCP)对丁丙诺啡和减少伤害服务的态度与PrEP处方开具之间的关系。对居住在美国南部和中西部、在联邦合格健康中心、农村健康诊所或其他符合HRSA条件的健康中心工作的初级保健提供者进行了一项Qualtrics小组调查。卡方检验用于探讨PrEP处方开具者和非处方开具者在将药物维持治疗(MOUD)、与药物相关的减少伤害措施纳入初级保健的态度上的显著差异。

结果

总体而言,62.1%(n = 254)的提供者样本报告在过去一年中至少开具了一张PrEP处方。与没有这些信念的提供者相比,认为改革丁丙诺啡豁免法使他们的工作更容易的提供者或表示有兴趣将纳洛酮分发和注射器交换纳入初级保健的提供者更有可能开具PrEP处方。来自较大机构且接受过传染病专业培训的提供者更有可能开具PrEP处方。

结论

本研究结果表明,更愿意将减少伤害服务纳入初级保健的提供者在过去一年中更有可能开具PrEP处方。对纳洛酮、注射器交换和丁丙诺啡态度更积极的初级保健提供者在过去一年中更有可能开具PrEP处方。联合干预可能是减少吸毒危害(包括药物过量和HIV感染)的一个有前景的途径,适用于吸毒人群。

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Buprenorphine and its formulations: a comprehensive review.丁丙诺啡及其制剂:全面综述。
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