Zhou Liming, Zhao Manhan, Zhai Yifei, Lin Qiong
School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China.
Cells. 2025 Aug 28;14(17):1335. doi: 10.3390/cells14171335.
The Mediator complex plays a key role in gene transcription. In particular, the interaction of the Mediator complex with nuclear receptors, the known transcription factors, regulates multiple nuclear receptor-mediated gene transcription pathways and associated cellular functions. Dysregulation of the interaction of the Mediator complex with nuclear receptors results in many pathological processes, such as cancer, metabolic and neuronal diseases. Thus, understanding of the mechanism by which the Mediator complex regulates the nuclear receptor-mediated transcriptional activity and biological function is crucial for therapy of both the Mediator complex- and nuclear receptor-associated diseases. In this review article, we attempt to summarize current research progress in the interaction of the Mediator complex with nuclear receptors and the associated nuclear receptor transcriptional signaling pathways, explore the clinical potential of the Mediator complex as a therapeutic target, and provide new perspectives for the treatment of diseases associated with the Mediator complex and nuclear receptors.
中介体复合物在基因转录中起关键作用。特别是，中介体复合物与核受体（已知的转录因子）的相互作用，调节多种核受体介导的基因转录途径及相关细胞功能。中介体复合物与核受体相互作用的失调会导致许多病理过程，如癌症、代谢和神经疾病。因此，了解中介体复合物调节核受体介导的转录活性和生物学功能的机制，对于治疗与中介体复合物和核受体相关的疾病至关重要。在这篇综述文章中，我们试图总结中介体复合物与核受体相互作用以及相关核受体转录信号通路的当前研究进展，探讨中介体复合物作为治疗靶点的临床潜力，并为治疗与中介体复合物和核受体相关的疾病提供新的视角。
