Mutations in Colorectal Adenocarcinoma: Incidence and Association with Histological Features with Particular Reference to in a Multicenter GIPAD Real-World Study.

INTRODUCTION

Colorectal cancer (CRC) is the third most frequent malignancy and the second cause of cancer-related death worldwide. CRC is characterized by morphologic and biological heterogeneity, and molecular profiling is required to select appropriate treatment in the metastatic setting. Mutations in are detected in approximately 40% of CRCs, with prognostic and predictive value, and with the most frequent being p.G12D. Nonetheless, there are few data on the morphologic features in -mutated CRCs.

MATERIALS AND METHODS

We retrospectively collected clinicopathological features and molecular profiles of CRCs in a multicenter cohort.

RESULTS

A total of 2816 patients from 12 centers were included. mutation was found in 47.4% of cases; was detected in 23.9%, with different mutation frequencies between centers. Clinicohistological features associated with mutation included younger patient age (≤70 years of age), higher prevalence in males (58.6%), NOS histotype (87.1%), low pathologic grade (73.9%), high grade budding-Bd3 (43.8%), and tumoral lympho-vascular invasion (68.9%).

CONCLUSIONS

Recent data have pinpointed the prognostic and predictive value of mutation, and our results contribute to understanding its biology, with particular focus on peculiar clinicopathological features. Moreover, we found significant differences in pathology reports and assays for molecular profiling in different centers, which can affect a standardized therapeutic approach in CRC.