整合素α2通过激活AKT/FOXO3A信号通路介导肝细胞癌对乐伐替尼的耐药性。

ITGA2 Mediates the Resistance of Hepatocellular Carcinoma to Lenvatinib by Activating the AKT/FOXO3A Signaling Pathway.

作者信息

Gong Kai, Xu Bin, Gong Lian, Zhong Ming, Han Chun, Liu Yuechuan, Yin Zeli, Liang Xiangnan, Wang Qiuxiang, Ye Genhua, Sun Binwen, Wang Liming

机构信息

Engineering Research Center for New Materials and Precision Treatment Technology of Malignant Tumors Therapy, The Second Affiliated Hospital, Dalian Medical University, Dalian 116023, China.

Engineering Technology Research Center for Translational Medicine, The Second Affiliated Hospital, Dalian Medical University, Dalian 116023, China.

出版信息

Cancers (Basel). 2025 Aug 29;17(17):2846. doi: 10.3390/cancers17172846.

The global incidence of primary liver cancer ranks sixth among malignant tumors, while its mortality rate ranks third and is the second leading cause of cancer-related deaths in China [...].