吲达帕胺对犬肠系膜血管的舒张作用。
Vasodilator effect of indapamide in dog mesenteric vasculature.
作者信息
Miyazaki M, Morishita S, Toda N
出版信息
Jpn J Pharmacol. 1985 Nov;39(3):402-5. doi: 10.1254/jjp.39.402.
PMID:4094184
Abstract
Effects of indapamide, trichlormethiazide and hydralazine on isolated, perfused dog mesenteric vasculature and helical strips of the dog mesenteric artery were compared. It appears that indapamide-induced hypotension is associated with a direct relaxant action on arterial and arteriolar smooth muscle, whereas hydralazine acts exclusively on resistance vessels.
摘要
比较了吲达帕胺、三氯噻嗪和肼屈嗪对离体灌注犬肠系膜血管和犬肠系膜动脉螺旋条的作用。吲达帕胺所致的低血压似乎与对动脉和小动脉平滑肌的直接舒张作用有关，而肼屈嗪仅作用于阻力血管。
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