Akyakar Buket, Şahin İrem Nur, Ağagündüz Duygu, Szép Dávid, Budán Ferenc
Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06490, Turkey.
Department of Nutrition and Dietetics, Faculty of Health Sciences, İstanbul Beykent University, İstanbul 34398, Turkey.
Int J Mol Sci. 2025 Aug 26;26(17):8260. doi: 10.3390/ijms26178260.
Menopause is a natural and inevitable part of life for women, leading to many physical and psychological changes accompanied by declining estrogen levels. This systematic review aimed to evaluate the effect of curcumin, due to its antioxidant and anti-inflammatory properties, on postmenopausal outcomes in women. This comprehensive analysis of RCTs (randomized controlled trials) published in the last decade was selected through a search of PubMed, Wiley, Scopus, and Web of Science (PROSPERO Identifier: CRD42024549735). Study selection and data extraction were performed using exclusion and inclusion criteria according to the PICOS framework (P: Population, I: Intervention, C: Comparison, O: Outcomes, S: Study designs). Of the twelve studies that met the criteria, 11 had a low-risk bias, but reports were conflicting on serum estradiol levels, bone density markers, and vasomotor symptoms; no significant effects on physical, psychological, or sexual functions were observed. For cardiometabolic biomarkers, short-term curcumin intake showed no significant effects, while long-term interventions using bioavailable forms of curcumin showed improvements in serum fasting glucose, fasting insulin, HOMA-IR (Homeostatic Model Assessment of Insulin Resistance), and lipid parameters. There are a limited number of studies examining the effect of curcumin intake on menopause-related outcomes. While overdose has been observed in some studies attempting to restore estradiol levels, no significant effects have been observed. However, curcumin intake impacts postmenopausal symptoms (e.g., improving symptoms of osteoporosis) through its antioxidant and anti-inflammatory effects. Different forms and doses, combinations, and durations of interventions may influence outcomes. Better-designed studies are needed to understand the potential effects of curcumin intake during menopause.
更年期是女性生命中自然且不可避免的阶段，会导致许多生理和心理变化，同时雌激素水平下降。本系统评价旨在评估姜黄素因其抗氧化和抗炎特性，对女性绝经后结局的影响。通过检索PubMed、Wiley、Scopus和Web of Science（PROSPERO标识符：CRD42024549735），筛选了过去十年发表的关于随机对照试验（RCT）的综合分析。根据PICOS框架（P：人群，I：干预措施，C：对照，O：结局，S：研究设计）的排除和纳入标准进行研究选择和数据提取。在符合标准的12项研究中，11项存在低风险偏倚，但关于血清雌二醇水平、骨密度标志物和血管舒缩症状的报告相互矛盾；未观察到对身体、心理或性功能有显著影响。对于心脏代谢生物标志物，短期摄入姜黄素未显示出显著影响，而使用生物可利用形式的姜黄素进行长期干预则显示血清空腹血糖、空腹胰岛素、稳态模型胰岛素抵抗评估（HOMA-IR）和血脂参数有所改善。研究姜黄素摄入对绝经相关结局影响的研究数量有限。虽然在一些试图恢复雌二醇水平的研究中观察到了过量情况，但未观察到显著影响。然而，姜黄素摄入通过其抗氧化和抗炎作用影响绝经后症状（如改善骨质疏松症状）。不同的形式、剂量、组合和干预持续时间可能会影响结局。需要设计更完善的研究来了解绝经期间摄入姜黄素的潜在影响。
