Pušić Maja Novak, Marijan Robert, Klančič Teja, Knific Tamara, Ban Frangež Helena, Rižner Tea Lanišnik
Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Šlajmerjeva 3, 1000 Ljubljana, Slovenia.
Int J Mol Sci. 2025 Aug 28;26(17):8348. doi: 10.3390/ijms26178348.
Growth arrest-specific protein 6 (GAS6) has an important role in regulating the immune system. Recent studies have revealed its association with the pathophysiology of endometriosis and identified GAS6 as one of the hub genes and a biomarker candidate. Endometriosis is a common chronic inflammatory gynaecological disease of women of childbearing age. Due to surgical diagnosis, non-invasive biomarkers are urgently needed. We investigated GAS6 as a candidate biomarker for the diagnosis of endometriosis. Our case-control study included 284 patients and showed that plasma levels of GAS6 are significantly higher in patients with endometriosis compared to control patients. We calculated logistic regression models using GAS6, CA-125, and GAS6 together with CA-125, and added a series of clinical and lifestyle data collected before surgical diagnosis. A CA-125 model and a model including GAS6 and CA-125 showed the highest AUC values of 0.745 ± 0.04, while the model including CA-125, data on sport/recreation before surgery, and dysmenorrhea score reached an AUC of 0.767 ± 0.04. Our results indicate that GAS6 is increased in patients with endometriosis, but it cannot serve as a biomarker candidate.
生长停滞特异性蛋白6（GAS6）在调节免疫系统中发挥着重要作用。最近的研究揭示了其与子宫内膜异位症病理生理学的关联，并将GAS6确定为核心基因之一和生物标志物候选物。子宫内膜异位症是育龄期女性常见的慢性炎症性妇科疾病。由于需要手术诊断，因此迫切需要非侵入性生物标志物。我们研究了GAS6作为子宫内膜异位症诊断的候选生物标志物。我们的病例对照研究纳入了284名患者，结果显示，与对照患者相比，子宫内膜异位症患者的血浆GAS6水平显著更高。我们使用GAS6、CA - 125以及GAS6与CA - 125联合计算了逻辑回归模型，并添加了手术诊断前收集的一系列临床和生活方式数据。CA - 125模型以及包含GAS6和CA - 125的模型显示出最高的AUC值，为0.745±0.04，而包含CA - 125、手术前运动/娱乐数据和痛经评分的模型的AUC达到了0.767±0.04。我们的结果表明，子宫内膜异位症患者的GAS6水平升高，但其不能作为生物标志物候选物。
