Niu Yewei, Liu Chen, Li Peiyan, Zhao Jiawei, Jin Jiamin, Yang Jinfeng
Department of Immunology, Guilin Medical University, Guilin 541199, China.
Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541199, China.
Int J Mol Sci. 2025 Sep 4;26(17):8620. doi: 10.3390/ijms26178620.
Graft-versus-host disease (GVHD) is one of the most prevalent and life-threatening complications that can arise following allogeneic hematopoietic cell transplantation (allo-HCT). GVHD occurs when immune cells-primarily T cells-from the graft recognize host cells as foreign entities and initiate an immune response against host tissues. This immune reaction generally involves a diverse array of cytokines, including interleukins (ILs), which play a pivotal role in modulating the immune response, promoting inflammation, and sustaining immune tolerance. Members of the interleukin family are not only directly involved in the activation, proliferation, and differentiation of T cells but also regulate inflammatory responses and the migration of immune cells. Consequently, they significantly influence both the clinical manifestations and prognosis of GVHD. The objective of this study is to review recent advancements in research concerning interleukins and their role in the pathogenesis of GVHD. This study aims to elucidate how interleukins contribute to immune regulation, inflammatory responses, and clinical manifestations. Furthermore, we will discuss their potential as therapeutic targets, with the intention of providing novel insights and strategies for the clinical management of GVHD.
移植物抗宿主病（GVHD）是异基因造血细胞移植（allo-HCT）后可能出现的最常见且危及生命的并发症之一。当来自移植物的免疫细胞（主要是T细胞）将宿主细胞识别为外来实体并启动针对宿主组织的免疫反应时，就会发生GVHD。这种免疫反应通常涉及多种细胞因子，包括白细胞介素（ILs），它们在调节免疫反应、促进炎症和维持免疫耐受方面发挥着关键作用。白细胞介素家族成员不仅直接参与T细胞的激活、增殖和分化，还调节炎症反应和免疫细胞的迁移。因此，它们对GVHD的临床表现和预后都有显著影响。本研究的目的是回顾白细胞介素及其在GVHD发病机制中的作用的最新研究进展。本研究旨在阐明白细胞介素如何促进免疫调节、炎症反应和临床表现。此外，我们将讨论它们作为治疗靶点的潜力，以期为GVHD的临床管理提供新的见解和策略。
