Han Ye-Jin, Lee Hye-Jin, Geum Dong-Ho, Kim Jong-Hoon, Park Dong-Hyuk
Laboratory of Neurosurgery, Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
Department of Neurosurgery, Anam Hospital, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
Int J Mol Sci. 2025 Sep 6;26(17):8708. doi: 10.3390/ijms26178708.
Ischemic stroke is a neurological disorder resulting from localized brain injury due to focal cerebral ischemia, typically caused by the blockage of one or, in some cases, a few cerebral arteries. This arterial obstruction leads to hypoxia and energy failure, culminating in primary brain damage. Although reperfusion is critical to salvage viable tissue, it often intensifies injury through oxidative stress, inflammation, and cell death-a phenomenon called ischemia-reperfusion (I/R) injury. Milk fat globule-EGF factor 8 (MFG-E8), a multifunctional glycoprotein secreted by stem and immune cells, is a key regulator of inflammation and tissue repair. By modulating microglial activation, attenuating proinflammatory cytokine releases, and preserving neuronal integrity, MFG-E8 mitigates ischemia-reperfusion injury and emerges as a novel therapeutic target for ischemic stroke.
缺血性中风是一种由于局灶性脑缺血导致局部脑损伤引起的神经障碍，通常由一条或在某些情况下几条脑动脉阻塞所致。这种动脉阻塞会导致缺氧和能量衰竭，最终造成原发性脑损伤。尽管再灌注对于挽救存活组织至关重要，但它常常通过氧化应激、炎症和细胞死亡加剧损伤，这一现象称为缺血再灌注（I/R）损伤。乳脂肪球表皮生长因子8（MFG-E8）是一种由干细胞和免疫细胞分泌的多功能糖蛋白，是炎症和组织修复的关键调节因子。通过调节小胶质细胞活化、减少促炎细胞因子释放以及维持神经元完整性，MFG-E8减轻缺血再灌注损伤，并成为缺血性中风的一个新的治疗靶点。
