Lee Nae-Ho, Lim Beom Jin, Shin Jin Yong, Chung Yoon Kyu, Roh Si-Gyun
Department of Plastic and Reconstructive Surgery, College of Medicine, Jeonbuk National University, Jeonju 54907, Republic of Korea.
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea.
J Clin Med. 2025 Aug 25;14(17):5997. doi: 10.3390/jcm14175997.
: Cervicodorsal lipodystrophy, commonly referred to as "buffalo hump," has traditionally been associated with Human Immunodeficiency Virus (HIV)-related antiretroviral therapy. However, similar deformities may also occur independently of HIV treatment. This study aimed to investigate non HIV-associated buffalo hump as a potential clinical marker of underlying metabolic or endocrine disorders. : We retrospectively reviewed 12 HIV-negative patients who presented with cervicodorsal lipodystrophy between 2012 and 2022. Patient demographics, laboratory values, and imaging findings were analyzed. All patients underwent surgical resection of a hypertrophic fat pad. Exploratory statistical analyses were performed using Mann-Whitney U and Fisher's exact tests and Spearman's correlation analysis. : These 12 patients had a mean age of 56.92 ± 16.69 years and a mean Body Mass Index (BMI) of 30.15 ± 4.59 kg/m. Hypertension and diabetes were each present in 66.7% of patients, and hyperlipidemia in 75%. Three patients were newly diagnosed with metabolic disease. No significant differences were found between newly diagnosed and previously diagnosed patients in age (45.67 ± 21.46 vs. 60.67 ± 14.31 years, = 0.194) or BMI (32.44 ± 2.39 vs. 29.39 ± 4.99 kg/m, = 0.145). Group differences in hypertension, diabetes, hyperlipidemia, or liver dysfunction were also not significant (all > 0.49). No correlation was observed between age and BMI (ρ = -0.158, = 0.624). : Although the small sample size precludes definitive conclusions, the prevalence of obesity, hypertension, and diabetes in this cohort was notably higher than reported in Korean population-based surveys. These findings suggest that non HIV-associated buffalo hump may serve as an externally visible marker of systemic metabolic burden. Metabolic screening should be considered even in the absence of overt systemic disease.
颈背脂肪营养不良，通常被称为“水牛背”，传统上与人类免疫缺陷病毒（HIV）相关的抗逆转录病毒治疗有关。然而，类似的畸形也可能独立于HIV治疗而出现。本研究旨在调查非HIV相关的水牛背作为潜在的潜在代谢或内分泌紊乱临床标志物。
我们回顾性分析了2012年至2022年间12例出现颈背脂肪营养不良的HIV阴性患者。分析了患者的人口统计学特征、实验室检查值和影像学检查结果。所有患者均接受了肥厚脂肪垫的手术切除。使用Mann-Whitney U检验、Fisher精确检验和Spearman相关性分析进行探索性统计分析。
这12例患者的平均年龄为56.92±16.69岁，平均体重指数（BMI）为30.15±4.59kg/m²。66.7%的患者患有高血压和糖尿病，75%的患者患有高脂血症。3例患者新诊断为代谢性疾病。新诊断患者与既往诊断患者在年龄（45.67±21.46岁 vs. 60.67±14.31岁，P = 0.194）或BMI（32.44±2.39kg/m² vs. 29.39±4.99kg/m²，P = 0.145）方面无显著差异。高血压、糖尿病、高脂血症或肝功能障碍的组间差异也不显著（均P＞0.49）。年龄与BMI之间未观察到相关性（ρ = -0.158，P = 0.624）。
尽管样本量小无法得出明确结论，但该队列中肥胖、高血压和糖尿病的患病率明显高于韩国基于人群的调查报道。这些发现表明，非HIV相关的水牛背可能是全身代谢负担的一个外部可见标志物。即使在没有明显全身性疾病的情况下，也应考虑进行代谢筛查。
