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钝性肝损伤有无手术修复情况下的肥胖与短期预后:来自美国2005 - 2020年全国住院患者样本的证据

Obesity and short-term outcomes in blunt liver trauma with and without surgical repair: evidence from the United States Nationwide Inpatient Sample 2005-2020.

作者信息

Wee Sin-Yong, Li Chi, Su Wei-Ti, Ying Shih-Min, Wang Hao-Ping

机构信息

Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 5F.-36, No. 123-10, Dapi Road, Niaosong District, Kaohsiung City, 833401, Taiwan.

Department of Trauma Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan.

出版信息

Surg Endosc. 2025 Sep 13. doi: 10.1007/s00464-025-12210-5.

Abstract

BACKGROUND

To determine the influence of obesity on short-term outcomes in patients with blunt liver trauma.

METHODS

The US Nationwide Inpatient Sample (NIS) database 2005-2020 was reviewed to identify patients ≥ 18 years old with blunt liver trauma. Patients were categorized based on body mass index (BMI) into morbidly obese (BMI > 40 kg/m), obese (30 ≤ BMI ≤ 40 kg/m), and non-obese (BMI < 30 kg/m) groups.

RESULTS

A total of 4121 patients were included, representing an estimated 20,382 patients nationwide. The mean age was 46.4 years, and 51.0% were male. Both obese and morbidly obese patients had significantly increased risks of in-hospital mortality (obese: adjusted odds ratio [aOR] = 1.59, 95% confidence interval [CI] 1.05-2.14; morbidly obese: aOR = 2.43, 95% CI 1.61-3.65). Morbid obesity was associated with increased risks of acute kidney injury (AKI) (aOR = 1.90, 95% CI 1.50-2.41) and shock (aOR = 1.56, 95% CI 1.21-2.01). However, patients with non-morbid obesity had significantly lower risks of prolonged LOS (aOR = 0.61, 95% CI 0.50-0.75), non-routine discharge (aOR = 0.66, 95% CI 0.53-0.81), and complications (aOR = 0.69, 95% CI: 0.57-0.83) compared to non-obese individuals.

CONCLUSION

Patients with morbid obesity who sustain blunt liver trauma are at increased risk of in-hospital mortality, AKI, and shock compared to non-obese individuals. Despite higher mortality risk, non-morbid obese patients have a lower risk of prolonged LOS, non-routine discharges, and complications.

摘要

背景

确定肥胖对钝性肝损伤患者短期预后的影响。

方法

回顾2005 - 2020年美国全国住院患者样本(NIS)数据库,以识别年龄≥18岁的钝性肝损伤患者。根据体重指数(BMI)将患者分为病态肥胖(BMI>40kg/m)、肥胖(30≤BMI≤40kg/m)和非肥胖(BMI<30kg/m)组。

结果

共纳入4121例患者,估计全国有20382例患者。平均年龄为46.4岁,51.0%为男性。肥胖和病态肥胖患者的院内死亡风险均显著增加(肥胖:调整优势比[aOR]=1.59,95%置信区间[CI]1.05 - 2.14;病态肥胖:aOR=2.43,95%CI 1.61 - 3.65)。病态肥胖与急性肾损伤(AKI)风险增加(aOR=1.90,95%CI 1.50 - 2.41)和休克风险增加(aOR=1.56,95%CI 1.21 - 2.01)相关。然而,与非肥胖个体相比,非病态肥胖患者出现住院时间延长(aOR=0.61,95%CI 0.50 - 0.75)、非常规出院(aOR=0.66,95%CI 0.53 - 0.81)和并发症(aOR=0.69,95%CI:0.57 - 0.83)的风险显著降低。

结论

与非肥胖个体相比,遭受钝性肝损伤的病态肥胖患者院内死亡、急性肾损伤和休克的风险增加。尽管死亡风险较高,但非病态肥胖患者住院时间延长、非常规出院和并发症的风险较低。

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