Dang A Q, Faas F H, Carter W J
Lipids. 1985 Dec;20(12):897-902. doi: 10.1007/BF02534774.
The effects of hyper- and hypothyroidism on enzyme activities involved in phospholipid metabolism in the rat liver were studied. Hyperthyroidism significantly decreases activities of both microsomal acyl-CoA:glycero-3-phosphate acyltransferase (GPAT) (34%, p less than 0.01) and microsomal acyl-CoA:1-acylglycero-3-phosphocholine acyltransferase (GPCAT) (28-33%, p less than 0.01). This may contribute to the decreased proportions of certain unsaturated fatty acids found in microsomal phosphoglycerides in hyperthyroidism. Mitochondrial GPAT, phospholipase A2 and cytosol lysophospholipase are unaffected by hyperthyroidism. In contrast, hypothyroidism stimulates mitochondrial GPAT (38%, p less than 0.01) and microsomal GPCAT (14-19%) activities but decreases both mitochondrial phospholipase A2 (36%, p less than 0.01) and cytosol lysophospholipase (56%, p less than 0.01) activities. The increased GPCAT activity may contribute to the increased proportions of certain unsaturated fatty acids found in microsomal phosphoglycerides in hypothyroidism. Triiodothyronine (T3) treatment of the hypothyroid rat (25 micrograms/100 g body weight/day for four days) corrected phospholipase A2 and lysophospholipase activities to the level of the control rat, but failed to correct the increased mitochondrial GPAT activity and not only corrected but lowered GPCAT activity to the level of the hyperthyroid rat.
研究了甲状腺功能亢进和减退对大鼠肝脏磷脂代谢相关酶活性的影响。甲状腺功能亢进显著降低微粒体酰基辅酶A：甘油-3-磷酸酰基转移酶（GPAT）的活性（降低34%，p<0.01）以及微粒体酰基辅酶A：1-酰基甘油-3-磷酸胆碱酰基转移酶（GPCAT）的活性（降低28%-33%，p<0.01）。这可能导致甲状腺功能亢进时微粒体磷酸甘油酯中某些不饱和脂肪酸比例降低。甲状腺功能亢进对线粒体GPAT、磷脂酶A2和胞质溶磷脂酶无影响。相反，甲状腺功能减退会刺激线粒体GPAT的活性（增加38%，p<0.01）和微粒体GPCAT的活性（增加14%-19%），但会降低线粒体磷脂酶A2的活性（降低36%，p<0.01）和胞质溶磷脂酶的活性（降低56%，p<0.01）。GPCAT活性增加可能导致甲状腺功能减退时微粒体磷酸甘油酯中某些不饱和脂肪酸比例增加。用三碘甲状腺原氨酸（T3）处理甲状腺功能减退的大鼠（25微克/100克体重/天，持续4天），可使磷脂酶A2和溶磷脂酶的活性恢复到对照大鼠的水平，但未能纠正线粒体GPAT活性的增加，不仅纠正了GPCAT活性，还将其降低到甲状腺功能亢进大鼠的水平。
