Kozubski W, Stańczyk L
Neurol Neurochir Pol. 1985 Jul-Aug;19(4):302-7.
In 31 women with a history of migraine platelet aggregation was studied between migrainous attacks, and in 14 of them during an attack of migraine. The method of Born and Cross was used. The rates of the first and second phases of aggregation were calculated and the quantitative index of aggregation curve according to Cavallero was calculated. Adrenaline in concentrations of 2 and 4 micron M was used as the aggregating factor. No differences were found in the mean rates of the first phase of aggregation between the patients and the controls. The rate of the second phase in the time between migraine attacks was significantly higher in patients with migraine (p less than 0.001) than in healthy subjects. During migraine attack the mean rate of the second phase decreased significantly (p less than 0.02 and p less than 0.001). These changes of the rate of the second phase may be explained as due to disturbances in the release of the aggregating substances from platelets and accumulation of platelet-activating substances.
对31名有偏头痛病史的女性在偏头痛发作间期进行了血小板聚集研究，其中14名女性在偏头痛发作时进行了研究。采用Born和Cross的方法。计算了聚集的第一阶段和第二阶段的速率，并根据Cavallero计算了聚集曲线的定量指标。使用浓度为2和4微摩尔的肾上腺素作为聚集因子。患者和对照组在聚集第一阶段的平均速率上未发现差异。偏头痛患者在偏头痛发作间期第二阶段的速率显著高于健康受试者（p<0.001）。在偏头痛发作期间，第二阶段的平均速率显著下降（p<0.02和p<0.001）。第二阶段速率的这些变化可能是由于血小板聚集物质释放紊乱和血小板激活物质积累所致。
