A prospective study of duodenal laparoscopy-endoscopy cooperative surgery for superficial duodenal tumors, including periampullary and medial wall lesions.

BACKGROUND

Duodenal laparoscopy-endoscopy cooperative surgery (D-LECS) is a novel technique involving duodenal endoscopic submucosal dissection (ESD) followed by laparoscopic seromuscular suturing. However, D-LECS has not been standardized due to limited data.

METHODS

This single-center prospective study enrolled 20 patients with superficial nonampullary duodenal tumors (SNADETs) located in the descending or transverse part from August 2019 to December 2023. The primary endpoint was the clinical success rate of d-LECS, defined as the completion of scheduled D-LECS with complete resection and closure of the post-ESD ulcer. ESD was performed by the single endoscopist.

RESULTS

The median tumor size was 30 mm, with a median treatment time of 296 min for total D-LECS and 115 min for ESD. The clinical success rate was 100 %, with 100 % en bloc resection, 80 % R0 resection, and no recurrence. Eight lesions were located in the medial wall, including five periampullary tumors, all of which achieved complete closure of post-ESD ulcers by combining endoscopic clipping with laparoscopic suturing. Intraoperative perforation occurred in three cases but was immediately repaired with laparoscopic suturing. No postoperative perforations or bleeding were observed.

CONCLUSION

D-LECS is a minimally invasive and safe treatment for SNADTs, allowing for en bloc resection with a low risk of recurrence.